Faculty

REFEREED PUBLICATIONS

(a) Journals

1980s

• Walley KR, Grover M, Raff GL, Benge JW, Hannaford B, Glantz SA. Left ventricular dynamic geometry in the intact and open chest dog. Circ Res. 50:573‑589, 1982.

• Bye PTP, Esau SA, Walley KR, Macklem PT, Pardy RL. Ventilatory muscles during exercise in air and oxygen in normal men. J Appl Physiol. 56:464‑471, 1984.

• Walley KR, Becker CJ, Hogan RA, Teplinsky K, Wood LDH. Progressive hypoxemia limits left ventricular oxygen consumption and contractility. Circ Res. 63:849‑859, 1988.

• Chiu YC, Walley KR, Ford LE. Comparison of the effects on different inotropic interventions on force, velocity and power in rabbit myocardium. Circ Res. 65:1161‑1171, 1989.

1990s

• Walley KR, Schmidt GA. Therapeutic use of intrinsic positive end expiratory pressure: A novel approach in a single patient. Crit Care Med. 18:336‑337, 1990.

• Teplinsky K, O’Toole M, Olman M, Walley KR, Wood LDH. Effect of lactic acidosis on canine hemodynamics and left ventricular function. Am J Physiol. 258:H1193‑H1199, 1990.

• Yanos J, Keamy III MF, Leisk L, Hall JB, Walley KR, Wood LDH. The mechanism of respiratory arrest in inspiratory loading and hypoxemia. Am Rev Respir Dis. 141:933‑937, 1990.

• Cooper DJ, Walley KR, Wiggs BR, Russell JA. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis: a prospective, controlled clinical study. Ann Intern Med. 112:492‑498, 1990.

• Walley KR, Lewis TH, Wood LDH. Acute respiratory acidosis decreases left ventricular contractility but increases cardiac output in dogs. Circ Res. 67:628‑635, 1990.

• Walley KR, Cooper DJ. Diastolic stiffness impairs left ventricular function during hypovolemic shock in pigs. Am J Physiol. 260:H702-H712, 1991.

• Ronco JJ, Phang PT, Walley KR, Wiggs B, Fenwick JC, Russell JA. Oxygen consumption is independent of changes in oxygen delivery in severe adult respiratory distress syndrome. Am Rev Resp Dis. 143:1267-1273, 1991.

• Walley KR, Ford LE, Wood LDH. Effects of hypoxia and hypercapnia on the force‑velocity relation of rabbit myocardium. Circ Res. 69:1616-1625, 1991.

• Walley KR, Cooper DJ, Baile EM, Russell JA. Bicarbonate does not improve left ventricular contractility during resuscitation from hypovolemic shock in pigs. J Crit Care. 7:14-21, 1992.

• Cooper DJ, Walley KR, Dodek PM, Rosenberg F, Russell JA. Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis. Intens Care Med. 18:286-289, 1992.

• Segal JM, Phang PT, Walley KR. Low dose dopamine hastens onset of gut ischemia in a porcine model of hemorrhagic shock. J Appl Physiol. 73:1159-1164, 1992.

• Cooper DJ, Thompson CR, Walley KR, Gillis RP, Wolinski‑Walley PE, Schellenberg RR. Histamine decreases left ventricular contractility in normal human subjects. J Appl Physiol. 73:2530-2537, 1992.

• Cooper DJ, Herbertson MJ, Werner HA, Walley KR. Bicarbonate does not increase left ventricular contractility during L‑lactic acidemia in pigs. Am Rev Respir Dis. 148:317-322, 1993.

• Ronco JJ, Fenwick JC, Tweeddale MG, Wiggs BR, Phang PT, Cooper DJ, Cunningham KF, Russell JA, Walley KR. Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans. JAMA. 270:1724-1730, 1993.

• Lister DR, Rudston-Brown B, Warriner CB, McEwen J, Chan M, Walley KR. Carbon dioxide absorption is not linearly related to intraperitoneal carbon dioxide insufflation pressure in pigs. Anesthesiology. 80:129-136, 1994.

• Walley KR, Hebert PC, Wakai Y, Wilcox PG, Road JD, Cooper DJ. Decrease in left ventricular contractility after tumor necrosis factor-a infusion in dogs. J Appl Physiol. 76:1060-1067, 1994.

• Ronco JJ, Belzberg A, Phang PT, Walley KR, Dodek PM, Russell JA. No differences in hemodynamics, ventricular function and oxygen delivery in septic and nonseptic patients with the adult respiratory distress syndrome. Crit Care Med. 22:777-782, 1994.

• Wilcox PG, Wakai Y, Walley KR, Cooper DJ, Road J. Tumour necrosis factor a decreases in vivo diaphragm contractility in dogs. Am J Resp Crit Care Med. 150:1368-1373, 1994.

• Werner HA, Herbertson MJ, Walley KR. Amrinone increases ventricular contractility and diastolic compliance in endotoxemia. Am J Respir Crit Care Med. 152:496-503, 1995.

• Herbertson MJ, Werner HA, Goddard CM, Russell JA, Wheeler A, Coxson R, Walley KR. Antitumor necrosis factor-a prevents decreased ventricular contractility in endotoxemic pigs. Am J Respir Crit Care Med. 152:480-488, 1995.

• Herbertson MJ, Werner HA, Russell JA, Iversen K, Walley KR. Myocardial oxygen extraction ratio is decreased during endotoxemia in pigs. J Appl Physiol. 79:479-486, 1995.

• Cooper DJ, Schellenberg RR, Walley KR. Different effects of histamine H₁ and H₂ stimulation on left ventricular contractility in pigs. Am J Physiol. 269:H959-H964, 1995.

• Goddard CM, Allard MF, Hogg JC, Herbertson MJ, Walley KR. Prolonged leukocyte transit time in coronary microcirculation of endotoxemic pigs. Am J Physiol. 269:H1389-H1397, 1995.

• Herbertson MJ, Werner HA, Studer W, Russell JA, Walley KR. Decreased left ventricular contractility during porcine endotoxemia is not prevented by ibuprofen. Crit Care Med. 24:815-819, 1996.

• Goddard CM, Allard MF, Hogg JC, Walley KR. Myocardial morphometric changes related to decreased contractility after endotoxin. Am J Physiol. 270:H1446-H1452, 1996.

• Herbertson MJ, Werner HA, Walley KR. Nitric oxide synthase inhibition partially prevents decreased left ventricular contractility during endotoxemia. Am J Physiol. 270:H1979-H1984, 1996.

• Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol. 81:885-894, 1996.

• Humer MF, Phang PT, Friesen BP, Allard MF, Goddard CM, Walley KR. Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs. J Appl Physiol. 81:895-904, 1996.

• Axler O, Tousignant C, Thompson CR, Dalla’va-Santucci J, Phang PT, Russell JA, Walley KR. Comparision of transesophageal echocardiographic, Fick, and thermodilution cardiac output in critically ill patients. J Crit Care. 11:109-116, 1996.

• Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL. Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun. 64:4733-4738, 1996.

• Herbertson MJ, Werner HA, Walley KR. Platelet activating factor antagonism improves ventricular contractility in endotoxemia. Crit Care Med. 25:221-226, 1997.

• Walley KR, Collins RM, Cooper DJ, Warriner CB. Myocardial anaerobic metabolism occurs at a critical coronary venous P_O2 in Pigs. Am J Respir Crit Care Med. 155:222-228, 1997.

• Axler O, Tousignant C, Thompson CR, Dalla’va-Santucci J, Drummond A, Phang PT, Russell JA, Walley KR. Small hemodynamic effect of typical rapid volume infusions in critically ill patients. Crit Care Med. 25:965-970, 1997.

• Granton JT, Goddard CM, Allard MF, van Eeden S, Walley KR. Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits. Am J Respir Crit Care Med. 155:1977-83, 1997.

• Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL. Elevated levels of macrophage inflammatory protein-2 in severe murine peritonitis increases neutrophil recruitment and mortality. Infect Immun. 65:3847-3851, 1997.

• Rudston-Brown B, Draper PN, Warriner B, Walley KR, Phang PT. Venous gas embolism: a comparison of carbon dioxide and helium. Can J Anaesth. 44:1102-1107, 1997.

 

• Granton JT, Walley KR, Phang PT, Russell JA, Lichtenstein S. Assessment of three methods to reduce the influence of mathematical coupling on oxygen consumption and delivery relationships. Chest. 113:1347-1355, 1998.

• Giffin DM, Gow KW, Warriner CB, Walley KR, Phang PT. Oxygen uptake during peritoneal ventilation in a porcine model of hypoxemia. Crit Care Med. 26:1564-1568, 1998.

 

• Poon BY, Goddard CM, Leaf CD, Russell JA, Walley KR. L-2-oxothiazolidine-4-carboxylic acid prevents endotoxin-induced cardiac dysfunction. Am J Respir Crit Care Med. 158:1109-1113, 1998.

• Walley KR, Friesen BP, Humer MF, Phang PT. Small bowel tonometry is more accurate than gastric tonometry in detecting gut ischemia. J Appl Physiol. 85:1770-1777, 1998.

• Gow KW, Phang PT, Tebbutt-Speirs SM, English JC, Allard MF, Goddard CM, Walley KR. Effect of crystalloid administration on oxygen extraction in endotoxemic pigs. J Appl Physiol. 85:1667-1675, 1998.

• Goddard CM, Poon BY, Klut ME, Wiggs BR, van Eeden SF, Hogg JC, Walley KR. Leukocyte activation does not mediate myocardial leukocyte retention during endotoxemia in rabbits. Am J Physiol. 275:H1548-H1557, 1998.

• Walley KR. Mechanics and energetics of tumor necrosis factor-a in the left ventricle. Crit Care Med. 27:29-30, 1999.

• Saito Y, Walley KR, Klut ME, English D, D’Yachkova Y, Hogg JC, van Eeden SF. Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression. Am J Respir Crit Care Med. 159: 1469-1476, 1999.

• Walley KR, McDonald TE, Higashimoto Y, Hayashi S. Modulation of pro-inflammatory cytokines by nitric oxide in murine acute lung injury. Am J Respir Crit Care Med. 160:698-704, 1999.

• Simms MG, Walley KR. Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1 dependent adhesion. Am J Physiol. 277:H253-H260, 1999.

• Herbertson MJ, Russell JA, Walley KR. Myocardial oxygen consumption during dobutamine infusion in endotoxemic pigs. J Crit Care. 14:125-132, 1999.

2000

• Uusaro A. Russell JA. Walley KR. Takala J. Gastric-arterial Pco₂ gradient does not reflect systemic and splanchnic hemodynamics or oxygen transport after cardiac surgery. Shock. 14:13-17, 2000

• Uusaro A, Chittock DR, Russell JA, Walley KR. Stress test and gastric-arterial Pco₂ measurement improve prediction of successful extubation. Crit Care Med. 28:2320-2326, 2000.

• Walley KR. Many roles of nitric oxide in regulating cardiac function in sepsis. Crit Care Med. 28:2135-2137, 2000.

• Russell JA, Singer J, Bernard GR, Wheeler A, Fulkerson W, Hudson L, Schein R, Summer W, Wright P, Walley KR. Changing pattern of organ dysfunction in early human sepsis is related to mortality. Crit Care Med. 28:3405-3411, 2000.

• McDonald TE, Grinman MN, Carthy CM, Walley KR. Endotoxin infusion in rats induces apoptotic and survival pathways in the heart. Am J Physiol. 279:H2053-H2061, 2000.

• Volpatti C, Leathley M, Walley KR, Dodek PM. Time-weighted nursing demand is a better predictor than midnight census of nursing supply in an Intensive Care Unit. J Crit Care. 15:147-150, 2000.

• Holmes CL, Russell JA, Walley KR. Sepsis: Is there room for vasopressin? Sepsis. 4:169-175, 2000.

2001

• Albert R, Angus D, Bion J, Chiche J-D, Epstein S, Evans T, Fagon J-Y, Ranieri M, Sznajder JI, Torres A, Walley KR, International Consensus Conferences in Intensive Care Medicine: Non-invasive positive pressure ventilation in acute respiratory failure. Intensive Care Medicine. 27:166-178, 2001.

• Evans TW, Albert RK, Bion JF, Chiche J-D, Epstein SK, Fagon JY, Ranieri M, Sznajder JI, Torres A, Walley KR. International consensus conferences in Intensive Care Medicine: Noninvasive positive pressure ventilation in acute respiratory failure. Am J Respir Crit Care Med. 163:283-291, 2001.

• Evans TW. Albert RK. Angus DC. Bion JF. Chiche JD. Epstein SK. Fagon JY. Ranieri M. Sznajder JI. Torres A. Walley KR. Noninvasive positive pressure ventilation in acute respiratory failure: Report of an international consensus conference in intensive care medicine, Paris, France, 13-14 April 2000. Reanimation Urgences. 10:112-125, 2001.

• McIntyre L, Walley KR. Importance of underlying mechanism and genotype on outcome of sepsis trials. Crit Care Med. 29:677-679, 2001.

• Holmes CL, Walley KR, Chittock DR, Lehman T, Russell JA. The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series. Intensive Care Med. 27:1416-21, 2001.

• Alscher KT, Phang PT, McDonald TE, Walley KR. Enteral feeding decreases gut apoptosis, permeability, and lung inflammation during murine endotoxemia. Am J Gastrointest Liver Physiol. 281:G569-G576, 2001.

• Holmes CL, Patel BM, Russell JA, Walley KR. Physiology of vasopressin relevant to management of septic shock. Chest. 120:989-1002, 2001.

 

• Holmes CL, Walley KR. Cardiovascular management of ARDS. Semin Respir Crit Care Med. 22:307-315, 2001.

• Cook RC, Goddard CM, Ashe KA, Chen K, Lichtenstein SV, Walley KR. Potential deleterious effect of b-adrenergic stimulation during warm-blood cardioplegia in rabbit hearts. J Invest Surg. 14:1-8, 2001.

• Dhingra VK, Uusaro A, Holmes CL, Walley KR. Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury. Anesthesiology. 95:947-953, 2001.

• Nakano Y, Coxson HO, Bosan S, Rogers RM, Sciurba FC, Keenan RJ, Walley KR, Pare PD, Hogg JC. Core to rind distribution of severe emphysema predicts outcome of lung volume reduction surgery. Am J Respir Crit Care Med. 164:2195-2199, 2001.

2002

• Boker A, Graham MR, Walley KR, McManus BM, Girling LG, Walker E, Lefevre GR, Mutch WAC. Improved arterial oxygenation with biologically variable or fractal ventilation using low tidal volumes in a porcine model of ARDS. Am J Respir Crit Care Med. 165:456-462, 2002.

• Patel BM, Chittock DR, Russell JA, Walley KR. Beneficial effects of short term vasopressin infusion during severe septic shock. Anesthesiology. 96:576-582, 2002.

• Zavorsky GS, Van Eeden SF, Walley KR, Russell JA. Circulating white blood cells affect red cell pulmonary transit times in endurance athletes during intense exercise. Med Sci Sports Exerc. 34:954-959, 2002.

• Ritacca FV, Simone C, Wax R, Craig KG, Walley KR. Pro/con clinical debate: Are steroids useful in the management of patients with septic shock? Crit Care. 6:113-116, 2002.

• Walley KR, Russell JA. Genetic predictors of adverse outcome from sepsis, ARDS and SIRS. Crit Care Rounds. 3(3):1-5, 2002.

• Zavorsky GS, Walley KR, Hunte GS, McKenzie DC, Sexsmith GP, Russell JA. Acute hypervolemia lengthens red cell pulmonary transit time during exercise in endurance athletes. Respir Physiol Neurobiol. 131:255-268, 2002.

• von Dadelszen P, Magee LA, Lee SK, Stewart SD, Simone C, Koren G, Walley KR, Russell JA. Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: A therapeutic opportunity? Crit Care Med. 30:1883-1892, 2002.

• Dhingra VK, Fenwick JC, Walley KR, Chittock DR, Ronco JJ. Lack of agreement between thermodilution and Fick cardiac output in critically ill patients. Chest. 122:990-997, 2002.

2003

• Walley KR, McDonald TE, Wang Y, Dai S, Russell JA. Albumin resuscitation increases cardiomyocyte contractility and decreases NOS II expression in rat endotoxemia. Crit Care Med. 31:187-194, 2003.

• Zavorsky GS, Walley KR, Russell JA. Red cell pulmonary transit times through the healthy human lung. Exp Physiol. 88(Pt 2):191-200, 2003.

• Holmes CL, Walley KR. Bad medicine: Low-dose dopamine in the ICU. Chest. 123(4):1266-75, 2003.

• Loucks EB, Godin DV, Walley KR, McManus BM, Rahimian R, Granville DJ, Hong JM, Aktary FM, Qayumi AK. Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. Can J Cardiol. 19(3):267-274, 2003.

• Zavorsky GS, Walley KR, Hunte GS, McKenzie DC, Sexsmith GP, Russell JA. Acute hypervolemia improves arterial oxygen pressure in athletes with exercise-induced hypoxemia. Exp Physiol. 88(4):555-564, 2003.

• Bosan S, Kareco T, Ruehlmann D, Chen KY, Walley KR. Three-dimensional capillary geometry in gut tissue. Microsc Res Tech. 1:61(5):428-437, 2003.

• Holmes CL, Russell JA, Walley KR. Genetic polymorphisms in sepsis and septic shock: Role in prognosis and potential for therapy. Chest. 124(3):1103-1115, 2003.

• Manocha S, Walley KR, Russell JA. Severe Acute Respiratory Distress Syndrome (SARS): A Critical Care Perspective. Crit Care Med. 31(11):2684-2692, 2003.

• Holmes CL, Walley KR. The evaluation and management of shock. Clin Chest Med. 24(4):775-789, 2003.

2004

• Groshaus HE, Manocha S, Walley KR, Russell JA. Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema. Crit Care. 8(4):234-42, 2004

• Davani EY, Dorscheid DR, Lee CH, Van Breemen C, Walley KR. Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton. Am J Physiol Heart Circ Physiol. 287(3):H1013-22, 2004.

• Fuchisawa A, van Eeden S, Magee, LA, Whalen B, Leung PCK, Russell JA, Walley KR, von Dadelszen P. Neutrophil apoptosis in pre-eclampsia, do steroids compound the relationship. J Obstet Gynaecol Res. 30(5), 342-348, 2004.

• von Dadelszen P, Magee LA, Devarakonda RM, Hamilton T, Ainsworth LM, Yin R, Norena M, Walley KR, Gruslin A, Moutquin J-M, Lee SK, Russell JA. The prediction of adverse maternal outcomes in pre-eclampsia. J Obstet Gynaecol Can. 26(10):871-80, 2004.

• Tebbutt SJ, He JQ, Burkett KM, Ruan J, Opushnyev IV, Tripp BW, Zeznik JA, Abara CO, Nelson CC, Walley KR. Microarray genotyping resource to determine population stratification in genetic association studies of complex disease. Bio Techniques. 37:977-985, 2004.

• Holmes CL, Walley KR. Vasopressin in the ICU. Curr Opin Crit Care. 10(6):442-448, 2004.

• Manocha S, Walley KR. Activated protein C: beyond 28 days. Crit Care Med. 32(11):2348-9, 2004.

2005

• Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, Mannose Binding Lectin and Toll-Like Receptor-2 are Associated with Increased Prevalence of Infection in Critically Ill Adults. Crit Care Med. 33(3):638-644, 2005.

• Sutherland AM, Walley KR, Manocha S, Russell JA. The association of interleukin 6 haplotype clades with mortality in critically ill adults. Arch Int Med. 165:75-82,

• Prasongsukarn K, Abel JG, Jamieson WR, Cheung A, Russell JA, Walley KR, Lichtenstein SV. The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery: A prospective randomized trial. J Thorac Cardiovasc Surg. 130(1):93-8, 2005.

• Shaw D, Russell JA, Walley KR. Pharmacogenomics in sepsis and septic shock. Drug Dev Res. 64:181-194, 2005.

• Wattanathum A, Manocha S, Groshaus H, Russell JA, Walley KR. Interleukin-10 Haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis. Chest. 128(3):1690-8, 2005.

• Bateman RM, Walley KR. Microvascular resuscitation as a therapeutic goal in severe sepsis. Crit Care. 9 Suppl 4:S27-32, 2005.

2006

• Manocha S, Gordon AC, Salehifar E, Groshaus H, Walley KR, Russell JA. Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injury. Crit Care. 10(1):R12, 2006.

• Lee KWJ, Hill JS, Walley KR, Frohlich JJ. Relative value of multiple plasma biomarkers as risk factors for coronary artery disease and death in an angiography cohort. CMAJ. 174(4):461-466, 2006.

• Walley DC, Tripp BW, Song YC, Walley KR, Tebbutt SJ. MACGT: multi-dimensional automated clustering genotyping tool for analysis of microarray-based mini-sequencing data. Bioinformatics. 22(9):1147-1149, 2006.

• Cooper DJ, Pellegrino V, Walley KR. Vasopressin: the preferred vasopressor in sepsis? Not today, not yet. Crit Care Resusc. 8(3):239-40, 2006.

• Davani EY, Boyd JH, Dorscheid DR, Wang Y, Meredith A, Chau E, Singhera GK, Walley KR. Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice. Cardiovasc Res. 72:134-142, 2006.

• Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR. Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-κB dependent inflammatory response. Cardiovasc Res. 72(3):384-93, 2006.

2007

• Walley KR, Russell JA. Protein C –1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med. 35(1):287-90, 2007.

• Manocha S, Russell JA, Sutherland AM, Wattanathum A, Walley KR. Fibrinogen-ß gene haplotype is associated with mortality in sepsis. J Infect. 54(6):572-7, 2007.

• Tokunaga C, Bateman RM, Boyd, J, Wang Y, Russell JA, Walley KR. Albumin Resuscitation Improves Ventricular Contractility and Myocardial Tissue Oxygenation in Rat Endotoxemia. Crit Care Med. 35(5):1341-7, 2007.

• Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR. Myocardial hypoxia-inducible HIF-1 alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol. 293:H448-H456, 2007.

• Bateman RM, Hodgson KC, Kohli K, Knight D, Walley KR. Endotoxemia increases the clearance of mPEGylated 5000-MW Quantum Dots as revealed by multiphoton microvascular imaging. J Biomed Opt. 12(6):064005, 2007.

• Menzies J, Magee LA, Macnab YC, Ansermino JM, Li J. Douglas MJ, Gruslin A, Kyle P, Lee SK, Moore MP, Moutquin JM, Smith GN, Walker JJ, Walley KR, Russell JA, von Dadelszen P. Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes. Hypertens Pregnancy. 26(4):447-62, 2007

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2008

• Boyd JH, Chau EH, Tokunanga C, Bateman RM, Haljan G, Davani EY, Wang Y, Walley KR. Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism. Crit Care. 12(1):R2, 2008.

• Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D (for the VASST Investigators). Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med. 358:877-887, 2008. PMID

• Boyd JH, Kan B, Roberts H, Wang Y, Walley KR. S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 102(10):1239-1246, 2008.

• Russell JA, Wellman H, Walley KR. Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry. Hum Genet 123(6):661-663, 2008

• Holmes CL, Walley KR. Arginine vasopressin in the treatment of vasodilatory septic shock. Best Practice Res Clin Anaesthesiol. 22(2), 275-286, 2008.

• Boyd JH, Walley KR. Is there a role for sodium bicarbonate in treating lactic acidosis from shock? Curr Opin Crit Care. 14(4):379-83, 2008.

• Wurfel MM, Gordon AC, Holden TD, Radella F, Strout J, Kajikawa O, Ruzinski JT, Rona G, Black RA, Stratton S, Jarvik GP, Hajjar AM, Nickerson DA, Rieder M, Sevransky J, Maloney JP, Moss M, Martin G, Shanholtz C, Garcia JC, Gao L, Brower B, Barnes KC, Walley KR, Russell JA, Martin TR. Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med. 178(7):710-20, 2008.

• Boyd JH, Holmes CL, Wang Y, Roberts H, Walley KR. Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R. Resuscitation. 79(2):325-31, 2008.

2009

• Russell JA, Walley KR, Gordon AC, Cooper DJ, Hébert PC, Singer J, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D for the Vasopressin and Septic Shock Trial (VASST) Investigators. Interaction of vasopressin infusion, corticosteroid treatment and mortality of septic shock. Crit Care Med. 37(3):811-8, 2009. PMID 19237882.

• Shaw DM, Sutherland AM, Russell JA, Lichtenstein SV, Walley KR. Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery. Crit Care. 13(1):R9, 2009.

• Murkin JM, Walley KR. Genetic susceptibility to inflammatory injury and various adverse outcomes. J Extra Corpor Technol. 41(1):43-9, 2009.

• Boyd JH, Walley KR. The role of echocardiography in hemodynamic monitoring. Curr Opin Crit Care. 15(3):239-43, 2009.

• Lamarche Y, Cheung A, Walley KR, Dodek P. Combined use of extracorporeal membrane oxygenation and activated protein C for severe acute respiratory distress syndrome and septic shock. J Thoracic Cardiovasc Surg. 138(1):246-247, 2009.

• Sutherland AM, Walley KR. Bench-to-Bedside Review: Association of Genetic Variation with Sepsis. Critical Care. 13:210, 2009.

• Indrambarya T, Boyd JH, Wang Y, McConechy M, Walley KR. Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. Crit Care 13(3):R98, 2009.

• Holmes CL, Walley KR. Vasoactive drugs for vasodilatory shock in ICU. Curr Opin Crit Care. 15: 398-402, 2009.

• Nakada E, Walley KR, Nakada T, Hu Y, von Dadelszen P, Boyd JH. Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells. Placenta. 30(9):774-779, 2009.

2010

• Gordon AC, Russell JA, Walley KR, Singer J, Ayers D, Storms MM, Holmes CL, Hébert PC, Cooper DJ, Mehta S, Granton JT, Cook DJ, Presneill JJ, for the Vasopressin and Septic Shock Trial (VASST) Investigators. The effects of vasopressin on acute kidney injury in septic shock. Intensive Care Med. 36(1):83-91, 2010.

• Nakada TA, Russell JA, Boyd JH, Aguirre-Hernandez R, Thain KR, Thair SA, Nakada E, McConechy M, Walley KR. β2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock. Am J Respir Crit Care Med. 181(2):143-149, 2010. PMID: 19850944.

• Clive Landis R, Murkin JM, Stump DA, Baker RA, Arrowsmith JE, De Somer F, Dain SL, Dobkowski WB, Ellis JE, Falter F,Fischer G, Hammon JW, Jonas RA, Kramer RS, Likosky DS, Paget Milsom F, Poullis M, Verrier ED, Walley K, Westaby S.Consensus statement: minimal criteria for reporting the systemic inflammatory response to cardiopulmonary bypass. Heart Surg Forum. 13(2):E116-23, 2010.
• Russell JA, Walley KR. Vasopressin and its immune effects in septic shock. J Innate Immun. 2:446-360, 2010.

• Maybauer MO, Walley KR. Best vasopressor for advanced vasodilatory shock: Should vasopressin be part of the mix? Intensive Care Med. 36:1484-1487, 2010.

• Cohn SM, Blackbourne LH, Landry DW, Proctor KG, Walley KR, Wenzel V. San Antonio vasopressin in shock symposium report. Resuscitation. 81:1473-1475, 2010.
• Henderson WR, Griesdale DEG, Walley KR, Sheel, AW. Clinical Review: Guyton – the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output. Crit Care 14(6):243, 2010.

2011

• Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 38(2):259-265, 2011. PMID: 20975548
• von Dadelszen P, Payne B, Li J, Ansermino JM, Broughton-Pipkin F, Cote AM, Douglas JM, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, Smith GN, Walker JJ, Walley KR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA for Study Group. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet, 377(9761):219-227, 2011.
• Walley KR. Use of central venous oxygen saturation to guide therapy. Am J Respir Crit Care Med, 184: 514-520, 2011.

• Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Russell A single nucleotide polymorphism in NF-kB inducing kinase is associated with mortality in septic shock. J Immunol. 15:186(4):2321-2328, 2011. PMID: 21257964

 

• Nakada TA, Russell JA, Wellman H, Boyd JH, Nakada E, Thain KR, Thair SA, Hirasawa H, Oda S, Walley KR. Leucyl/cystinyl aminopeptidase gene variants in septic shock. Chest, 139:1042-1049, 2011. PMID: 21330387.

• Nakada TA, Russell JA, Boyd JH, McLaughlin L, Nakada E, Thair SA, Hirasawa H, Oda S, Walley KR. Association of angiotensin II type 1 receptor-associated protein (AGTRAP) gene polymorphism with increased mortality in septic shock. Crit Care Med. 39(7):1641-1648, 2011. PMID: 21423001.

• Nakada E, Nakada T, Walley KR, McConechy M, McLaughlin L, von Dadelszen P, Shozub M, Boyd JH. mRNA induces RANTES production in trophoblast cells via TLR3 only when delivered intracellularly using lipid membrane encapsulation. Placenta. 32(7):500-505, 2011.

 

• Millman AL, Payne B, Qu Z, Douglas MJ, Hutcheon JA, Lee T, Magee LA, Walley KR, von Dadelszen P. Oxygen saturation as a predictor of adverse maternal outcomes in women with preeclampsia. J Obstet Gynaecol Can. 33(7):705-714, 2011.

 

• Sutherland AM, Walley KR, Nakada TA, Sham AHP, Wurfel MM, Russell JA. A Non-Synonymous Polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands. J Innate Immun, 3(5):447-58, 2011. PMID: 21576904.

• Russell JA, Boyd JH, Nakada T, Thair SA, Walley KR. Molecular mechanisms of sepsis. Contrib Microbiol. 17:48-85, 2011.

 

• Mehta S, Granton J, Lapinsky S, Newton G, Bandayrel K, Little A, Cook DJ, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper KJ, Holmes CL, Hebert P, Gordon AC, Presneill J, Russell JA, for the VASST Investigators. Agreement in electrocardiogram interpretation in patients with septic shock. Crit Care Med. 39(9):2080-2086, 2011. PMID: 21849822.

• Budinger GR, Walley KR. Predicting mortality in patients with acute lung injury. Am J Respir Crit Care Med. 184(4):394-395, 2011.

 

• Vincent JL, Rhodes A, Perel A, Martin GS, Rocca GD, Vallet B, Pinsky MR, Hofer CK, Teboul JL, de Boode WP, Scolletta S, Vieillard-Baron A, De Backer D, Walley KR, Maggiorini M, Singer M. Clinical review: Update on hemodynamic monitoring – a consensus of 16. Crit Care 15(4):229, 2011.

 

• Mathur S, Walley KR, Wang Y, Indrambarya T, Boyd JH. Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2. Circ J. 75(10):2445-52, 2011.

 

• Mathur S, Walley KR, Boyd JH. The TLR9 ligand CpG-C attenuates acute inflammatory cardiac dysfunction. Shock. 36(5):478-483, 2011.

 

• Nakada T, Russell JA, Boyd JH, Walley KR. IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care. 15(5):R254, 2011.

 

2012

 

• Wacharasint P, Nakada T, Boyd JH, Russell JA, Walley KR. Normal-range blood lactate concentration in septic shock is prognostic and predictive. Shock. 38(1):4-10, 2012. PMID: 22552014.

• Thain KR, Nakada T, Boyd JH, Russell JA, Walley KR. A common polymorphism in the 5’ region of the human protein C gene binds USF1. Thromb Res. 130:451-457, 2012

 

• Walley KR. Expanding our thinking regarding early goal directed therapy. Crit Care Med. 40(10):2911-2912, 2012.

 

• Gordon AC, Wang, N, Walley KR, Ashby D, Russell JA. The cardiopulmonary effects of vasopressin compared to norepinephrine in septic shock. Chest. 142(3):593-605, 2012. PMID: 22518026.

• Wacharasint P, Nakada T, Boyd JH, Russell JA, Walley KR. AA genotype of IL-8 -251A/T is associated with low PaO₂/FiO₂ in critically ill patients and with increased IL-8 expression. Respirology. 17(8):1253-60, 2012. PMID: 22897124.

• Bateman RM, Ellis CG, Suematsu M, Walley KR. S-Nitrosoglutathione acts as a small molecule modulator of human fibrin clot architecture. PLoS ONE 7(8):e43660, 2012.

 

2013

 

• Chang AC, Patenaude A, Lu K, Fuller M, Ly M, Kyle A, Golbidi S, Wang Y, Walley K, Minchinton A, Laher I, Karsan A. Notch-dependent regulation of the ischemic vasodilatory response. Atheroscler Thromb Vasc Biol 33(3):510-512, 2013.

 

• Mehta S, Granton J, Gordon AC, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Cook DJ, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J., Russell JA. Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Crit Care 17(3):R117, 2013. PMID: 23786655.

• Russell JA, Fjell C, Hsu JL, Lee T, Boyd J, Thair S, Singer J, Patterson AJ, Walley KR. Vasopressin compared to norepinephrine augments the decline of plasma cytokine levels in septic shock. Am J Resp Crit Care Med. 188(3):356-64, 2013. PMID: 23796235.

• Wacharasint P, Boyd JH, Russell JA, Walley KR. One size does not fit all in severe infection: obesity alters outcome, susceptibility, treatment, and inflammatory response. Crit Care. 17:R122, 2013. PMID: 23786836.

• Russell JA, Walley KR. Update in sepsis 2012. Am J Resp Crit Care Med. 187(12):1303-1307, 2013. PMID: 23767902

• Walley KR. Biomarkers in Sepsis. Curr Infect Dis Rep. 15(5):413-20, 2013. PMID: 23975686.

• Douglas JJ, Walley KR. Metabolic changes in cardiomyocytes during sepsis. Crit Care. 17:186, 2013. PMID: 24053782.

• Wong HR, Lindsell CJ, Pettila V, Meyer NJ, Thair SA, Karlsson S, Russell JA, Fjell CD, Boyd JH, Ruokonen E, Shashaty MGS, Christie JD, Hart KW, Lahni P, Walley KR. A multi-biomarker-based outcome risk stratification model for adult septic shock. Crit Care Med. 42(4):781-789, 2013. PMID: 24335447.

• Fjell C, Thair S, Hsu JL, Walley KR, Russell JA, Boyd J. Cytokines and signaling molecules predict clinical outcomes in sepsis. PLoS ONE 14:8(11):e79207, 2013. PMID: 24244449.

2014

• Douglas, JJ, Tsang J, Walley KR. Sepsis and the innate-like response. Intensive Care Med. 40(2):249-251, 2014. PMID: 24322274.

• Anantasit N, Boyd JH, Russell JA, Fjell CD, Lichtenstein SV, Walley KR. Prolonged QTc affects short and long term outcomes in patients with normal left ventricular function undergoing cardiac surgery. J Thoracic Cardiovasc Surg. 147(5):1627-1633, 2014. PMID: 24485960.

• Boyd JH, McConechy M, Walley KR. Acute organ injury is associated with alterations in the cell-free plasma transcriptome. Intens Care Med Exp 2(1):5, 2014. PMID: 26266904.

• Anantasit N, Boyd JH, Walley KR, Russell JA. Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock. Crit Care Med. 42(8):1812-20, 2014. PMID: 24919159.

• Linder A, Fjell C, Levin A, Walley KR, Russell JA, Boyd JH. Small acute increases in serum creatinine are associated with decreased long term survival in the critically ill. Am J Resp Crit Care Med. 189(9):1075-81, 2014. PMID: 24601781.

• Walley KR. Deeper understanding of mechanisms contributing to sepsis-induced myocardial dysfunction. Crit Care. 18:137, 2014. PMID: 25033297.

• Douglas JJ, Walley KR. Fluid choices impact outcome in septic shock. Current Opinion in Critical Care. 20(4):378-84, 2014. PMID: 24979550.

• Morty RE, Walley KR. A step forward toward the clinical application of palifermin for acute respiratory distress syndrome? Am J Respir Crit Care Med. 189(12):1455-1456, 2014. PMID: 24930526.

• Wunderink RG, Walley KR. Update in sepsis and pulmonary infections 2013. Am J Resp Crit Care Med. 190(1):25-31, 2014. PMID: 24983219.

• Linder A, Guh, D, Boyd JH, Walley KR, Anis A, Russell JA. Long-term (10-year) mortality of younger previously healthy patients with severe sepsis/septic shock is worse than that of patients with nonseptic critical illness and of the general population. Crit Care Med. 42(10):2211-2218, 2014. PMID: 25054672.

• Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP. A functional synonymous coding variant in the IL1RN gene associates with survival in septic shock. Am J Respir Crit Care Med. 190(6):656-664, 2014. PMID: 25089931.

• Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada T-A, Fjell CD, Thair SA, Cirstea MS, Boyd JH. PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Science Transl Med. 6:258ra143, 2014. PMID: 25320235.

• Walley KR. Aging and the intramyocardial inflammatory response. Crit Care. 18:638, 2014. PMID: 25672938.

• Walley PE, Walley KR, Goodgame B, Punjabi V, Sirounis D. A practical approach to goal-directed echocardiography in the critical care setting. Crit Care. 18:681, 2014. PMID: 25672460.

2015

• Nakada T, Russell JA, Boyd JH, Thair SA, Walley KR. Identification of a non-synonymous polymorphism in the SVEP1 gene associated with altered clinical outcomes in septic shock. Crit Care Med. 43:101-108, 2015. PMID: 25188548.

• Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamak R, Chiche J-D, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bolls F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri M, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider M, Reinhart K, Holloway PAH,, Knight J, Garrard CS, Russell JA, Walley KR, Stuber F, Hill AVS, Hinds CJ, for the ESICM/ECCRN GenOSept Investigators. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. The Lancet Respiratory Medicine. 3:53-60, 2015. PMID: 25533491.

• Bentzer P, Russell JA, Walley KR. Advances in sepsis research. Clinics in Chest Medicine. 36(3):521-530, 2015. PMID: 26304288.

• Wong HR, Walley KR, Pettila V, Meyer NJ, Russell JA, Karlsson S, Shashaty MGS, Lindsell CJ. Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers. 20(2):132-135, 2015. PMID: 25578228.

• Nakada T, Boyd JH, Russell JA, Aguirre-Hernandez R, Wilkinson MD, Thair SA, Nakada E, McConechy MK, Fjell CD, Walley KR. VPS13D gene variant is associated with altered IL-6 production and mortality in septic shock. J Innate Immun. 7(5):545-53, 2015. PMID: 25896417.

• Russell JA, Walley KR. Sepsis breakthroughs in 2014. F1000 Research 2015, 4(F1000 Faculty Rev):131, 2015.

• Walley KR, Francis GA, Opal SM, Stein EA, Russell JA, Boyd JH. The central role of PCSK9 in septic pathogen lipid transport and clearance. Am J Resp Crit Care Med. 192(11): 1275-86, 2015. PMID: 26252194.

 

2016

• Thair SA, Topchiy E, Boyd JH, Wang C, Cirstea M, Nakada TA, Fjell C, Wurfel M, Russell JA, Walley KR. TNFAIP2 inhibits early TNFα induced NF-kB signaling and decreases survival in septic shock patients. J Innate Immun. 8(1): 57-66, 2016. PMID: 26347487.

• Suetrong B, Walley KR. Lactic acidosis in sepsis: It’s not all anaerobic. Implications for diagnosis and management. Chest. 149(1): 252-261, 2016. PMID: 26378980.

• Wang R, Meyer NJ, Walley KR, Russell JA, Feng R. Causal genetic inference using haplotypes as instrumental variables. Genetic Epidemiology. 40(1): 35-44, 2016. PMID: 26625855.

• Gelinas J, Walley KR. Beyond the golden hours: caring for septic patients after the initial resuscitation. Clinics in Chest Med. 37(2): 347-365, 2016. PMID: 27229650.

• Bentzer P, Fisher J, Kong JHJ, Mörgelin M, Boyd J, Walley KR, Russell J, Linder A. Heparin Binding Protein is important for vascular leak in sepsis. Intens Care Med Exp. 4(1): 33, 2016. PMID:

• Boyd JH, Fjell C, Russell JA, Sirounis D, Cirstea MS, Walley KR. Increased plasma PCSK9 levels are associated with reduced endotoxin clearance and the development of acute organ failures during sepsis. J Innate Immun. 8(2): 211-220, 2016. PMID: 26756586.

• Linder A, Lee T, Fisher J, Singer J, Boyd J, Walley KR, Russell JA. Short term organ dysfunction is associated with long term (10-year) mortality of septic shock. Crit Care Med. 44(8): e728-e736, 2016. PMID: 27428136.

• Pisitsak C, Lee JGH, Boyd JH, Coxson HO, Russell JA, Walley KR. Increased ratio of visceral to subcutaneous adipose tissue in septic patients is associated with adverse outcome. Crit Care Med. 44(11): 1966-1973, 2016. PMID: 27513541.

• Bentzer P, Fjell C, Walley KR, Boyd J, Russell JA. Plasma cytokine levels predict response to corticosteroids in septic shock. Intens Care Med. 42(12): 1970-79, 2016. PMID: 27071387.

• Topchiy E, Cirstea M, Kong HJ, Boyd JH, Wang Y, Russell JA, Walley KR. Lipopolysaccharide is cleared from the circulation by hepatocytes via the Low Density Lipoprotein Receptor. PLoS ONE 11(5): e0155030, 2016. PMID 27171436.

• Fisher J, Douglas JJ, Linder A, Boyd JH, Walley KR, Russell JA. Elevated plasma angiopoietin-2 levels are associated with fluid overload, organ dysfunction, and mortality in human septic shock. Crit Care Med. 44(11): 2018-2027, 2016. PMID: 27441903.

• Walley KR. Left ventricular function: time-varying elastance and left ventricular aortic coupling. Crit Care. 20: 270, 2016. PMID: 27613430.

• Walley KR. Role of lipoproteins and proprotein convertase subtilisin/kexin type 9 in endotoxin clearance in sepsis. Current Opinion in Crit Care. 22: 464-469, 2016. PMID: 27552305.

• Walley KR. The cardiovascular system in critical illness. Current Opinion in Crit Care. 22(5):413-415, 2016. PMID: 27537111.

• Ryan HM, Sharma S, Magee LA, Ansermino JM, MacDonell K, Payne BA, Walley KR, von Dadelszen P. The usefulness of the APACHE II score in obstetric critical care: a structured review. J Obst Gynaecol Canada. 38(10): 909-918, 2016. PMID: 27720089.

• Walley KR. Genetic association studies identify unanticipated gene pathways influencing sepsis outcome. EBioMedicine. 12: 20-21, 2016. PMID: 27658739.

• Suetrong B, Pisitsak C, Boyd JH, Russell JA, Walley KR. Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients. Crit Care. 20:315, 2016. PMID: 27716310.

• Salehifar E, Arjmand ST, Aliyali M, Abedi S, Sharifpour A, Alipour A, Ala S, Eslami G, Bozorgi F, Mahdavi MR, Walley KR. Role of C-reactive protein and tumor necrosis factor-alpha in differentiating between ventilator-associated pneumonia and systemic inflammatory response syndrome without infectious etiology. Tanaffos 15(4):205-212, 2016.

• Lalu MM, Sullivan K, Mei S, Moher D, Strauss A, Fergusson DA, Stewart DJ, Jazi M, MacLeod M, Winston B, Marshall J, Hutton B, Walley KR, McIntyre L, on behalf of the Canadian Critical Care Translational Biology Group. Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to a first-in-human trial. eLife, pii: e17850, 2016. PMID: 27870924.

2017

• Pisitsak C, Walley KR. Does this patient have septic shock? Intens Care Med. 43(3): 429-432, 2017. PMID: 26754757.

• Aarvold ABR, Ryan HM, Magee LA, von Dadelszen P, Fjell C, Walley KR. Multiple Organ Dysfunction Score is superior to the obstetric-specific SOS score in predicting mortality in septic obstetric patients. Crit Care Med. 45(1): e49-57, 2017. PMID: 27618276.

• Cirstea M, Walley KR, Russell JA, Brunham lR, Genga KR, Boyd JH. Decreased high density lipoprotein level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis. J Crit Care. 38: 289-294, 2017. PMID 28013095.

• Walley KR. New approaches to modifying inotropy in sepsis-induced myocardial dysfunction. Crit Care Med. 45(4):754-756, 2017. PMID: 28291104.

• Russell JA, Lee T, Singer J, Boyd JH, Walley KR. The septic shock 3.0 definition and trials: A VASST experience. Crit Care Med.45(6):940-948, 2017. PMID: 28333757.

• Rush B, McDermid RC, Celi LA, Walley KR, Russell JA, Boyd JH. Association between chronic exposure to air pollution and mortality in the acute respiratory distress syndrome. Environmental Pollution. 224:352-356, 2017. PMID: 28202265.

• Roveran Genga K, Lo C, Cirstea M, Zhou G, Walley KR, Russell JA, Levin A, Boyd JH. Two-year follow-up of septic patients presenting with low HDL: the effect upon acute kidney injury, death and eGFR. J Intern Med. 281(5): 518-529, 2017. PMID: 28317295.

• Fisher J, Russell JA, Bentzer P, Parsons D, Secchia S, Mörgelin M, Walley KR, Boyd JH, Linder A. Heparin-Binding Protein (HBP): A causative marker and potential target for heparin treatment of human sepsis-induced acute kidney injury. Shock. 48(3): 313-320, 2017. PMID: 28319494.

• Rush B, Walley KR, Celi LA, Rajoriya N, Brahmania M. Palliative care access for hospitalized patients with end stage liver disease across the United States. Hepatology. 66(5):1585-1591. 2017. PMID: 28660622.

• Wiskar K, Celi LA, Walley KR, Fruhstorpher C, Rush B. Inpatient palliative care referral and 9-month hospital readmission in patients with congestive heart failure: a linked nationwide analysis. J Intern Med. 282(5): 445-451. 2017. PMID: 28741859.

• Ryan HM, Jones MA, Payne BA, Sharma S, Hutfield AM, Lee T, Ukah UV, Walley KR, Magee LA, von Dadelszen P. Validating the performance of the modified early obstetric warning system multivariable model to predict maternal intensive care unit admission. J Obstet Gynaecol Can. 39(9): 728-733.e3, 2017. PMID: 28566256.

2018

• Annane D, Mira JP, Ware LB, Gordon AC, Hinds CJ, Christiani DC, Sevransky J, Barnes K, Buchman TG, Heagerty PJ, Balshaw R, Lesnikova N, de Nobrega K, Wellman HF, Neira M, Mancini ADJ, Walley KR, Russell JA. Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis. Ann Intensive Care 8(1):16, 2018. PMID: 29388048.

• Kearns MJ, Walley KR. Tamponade: Hemodynamic and echocardiographic diagnosis. Chest. 153(5):1266-1275. 2018. PMID 29137910.

• Rush B, Wiskar K, Celi LA, Walley KR, Russell J, McDermot RC, Boyd J. Association of household income level and in-hospital mortality in patients with sepsis: A nationwide retrospective cohort analysis. J Intens Care Med. 33(10):551-556, 2018. PMID: 28385107.

• Rush B, Tyler PD, Stone DJ, Geisler BP, Walley KR, Celi LA. Outcomes of ventilated patients with sepsis who undergo interhospital transfer: A nationwide linked analysis. Crit Care Med. 46(1): e81-e86, 2018. PMID: 29068858.

• Walley KR. Mitigating microvascular leak during fluid resuscitation of hemorrhagic shock. Anesthesiology. 128(2): 252-253, 2018. PMID: 29232207.

• Nakada TA, Wacharasint P, Russell JA, Boyd JH, Nakda E, Thair SA, Shimada T, Walley KR. The IL-20 genetic polymorphism is associated with altered clinical outcome in septic shock.  J Innat Immune. 10(3):181-188, 2018. PMID: 29334679.

• McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, dos Santos C, Walley KR, Winston B, Fergusson DA. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am J Respir Crit Care Med. 197(3):337-347, 2018. PMID: 28960096.

• Wiskar KJ, Celi LA, McDermid RC, Walley KR, Russell JA, Boyd JH, Rush B. Patterns of palliative care referral in patients admitted with heart failure requiring mechanical ventilation. Am J Hosp Palliat Care. 35(4):620-626, 2018. PMID: 28826226.

• Lee JGH, Genga KR, Pisitsak C, Boyd JH, Leung AKK, Russell JA, Walley KR. Survival benefit of a low ratio of visceral to subcutaneous adipose tissue depends on LDL clearance versus production in sepsis. Crit Care. 22(1):58. 2018. PMID: 29510719.

• Genga K, Shimada T, Boyd JH, Walley KR, Russell JA. The understanding and management of organism toxicity in septic shock. J Innate Immun. 15:1-13. 2018. PMID: 29763894.

• Russell JA, Spronk P, Walley KR. Using multiple ‘omics strategies for novel therapies in sepsis. Intens Care Med. 44(4):509-511. 2018. PMID 29546534.

• Burlinson C, Sirounis D, Walley KR, Chau A. Sepsis in pregnancy and the puerperium. Int J Obstet Anesth. 36: 96-107, 2018. PMID: 29921485.

• Brunham LR, Lynch K, English A, Sutherland R, Weng J, Cho R, Wong GC, Aslam A, Francis GA, Khan ND, McManus B, Wood D, Walley KR, Leipsic J, Humphries KH, Krahn AD, Mancini GBJ, Pimstone S. The design and rationale of SAVE BC: The Study to Avoid Vascular Events in British Columbia. Clinical Cardiology. 41(7): 888-895. 2018. PMID: 29635745.

• Walley KR. Sepsis-induced myocardial dysfunction. Curr Opin Crit Care. 24(4):292-299. 2018. PMID: 29846206.

• Fisher J, Linder A, Bentzer P, Boyd J, Kong HJ, Lee T, Walley KR, Russell JA. Is Heparin-Binding Protein inhibition a mechanism of albumin’s efficacy in human septic shock? Crit Care Med. 46(5):e364-e374. 2018. PMID: 29406419.

• von Dadelszen P, Magee LA, Benton SJ, Hu Y, Ansermino M, Carleton B, Carter C, Douglas MJ, Janssen PA, Lee SK, Leung PCK, Li J, MacNab Y, Payne BA, Peng G, Rodger M, Skoll MA, Synnes A, Walley KR, Russell JA. Activated protein C as disease-modifying therapy in antenatal preeclampsia: An open-label, single arm safety and efficacy trial. Pregnancy Hypertension. 13:121-126. 2018. PMID: 30177038.

• Rush B, Walley KR. The emerging role of palliative care in the management of Canadians with heart failure. Can J Cardiol. 34(9):1114-1115. 2018. PMID: 30093302.

• Payne BA, Ryan H, Bone J, Magee LA, Aarvold AB, Mark Ansermino J, Bhutta ZA, Bowen M, Guilherme Cecatti J, Chazotte C, Crozier T, de Pont AJM, Demirkiran O, Duan T, Kallen M, Ganzevoort W, Geary M, Goffman D, Hutcheon JA, Joseph KS, Lapinsky SE, Lataifeh I, Li J, Liskonova S, Hamel EM, McAuliffe FM, O’Herlihy C, Mol BWJ, Seaward PGR, Tadros R, Togal T, Qureshi R, Vivian Ukah U, Vasquez D, Wallace E, Yong P, Zhou V, Walley KR, von Dadelszen P. Development and internal validation of the multivariable CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) clinical risk prediction model.  Crit Care. 22(1):278, 2018. PMID: 30373675.

• Russell JA, Wellman H, Walley KR. Vasopressin versus norepinephrine in septic shock: a propensity score matched efficiency retrospective cohort study in the VASST coordinating center hospital. J Intensive Care. 6:73. PMID: 30473792.

• Genga KR, Trinder M, Kong HJ, Li X, Leung AKK, Shimada T, Walley KR, Russell JA, Francis GA, Brunham LR, Boyd JH. CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis.  Sci Rep. 8(1):16764. 2018. PMID: 30425299.

• Genga KR, Lo C, Cirstea MS, Walley KR, Russell JA, Linder A, francis GA, Boyd JH. Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivors.  38:257-264. 2018. PMID: 30473376.

2019

• Trinder M, Genga KR, Kong HJ, Blauw LL, Lo C, Li X, Cirstea M, Wang Y, Rensen PCN, Russell JA, Walley KR, Boyd JH, Brunham LR. Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein levels and survival in sepsis. Am J Respir Crit Care Med. 199(7):854-862. 2019. PMID 30321485.

• Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. Identification of acute kidney injury sub-phenotypes with differing molecular signatures and response to vasopressin therapy.  Am J Respir Crit Care Med. 199(7):863-872. 2019. PMID 30334632.

• Walley KR, Boyd JH, Kong HJ, Russell JA. Low Low-Density Lipoprotein levels are associated with, but do not causally contribute to, increased mortality in sepsis. Crit Care Med. 47(3):463-466. 2019. PMID 30394916.

• Schlosser K, Wang J-P, dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ, Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. Effects of mesenchymal stem cell treatment on systemic cytokine levels in a phase 1 dose escalation safety trial of septic shock patients. Crit Care Med. 47(7):918-925, 2019. PMID: 30720538.

• Nakada TA, Takahashi W, Nakada E, Shimada T, Russell JA, Walley KR. Genetic polymorphisms in sepsis and cardiovascular disease Do similar risk genes suggest similar drug targets? Chest. 155(6):1260-1271, 2019 PMID: 30660782.

• De Backer D, Cecconi M, Lipman J, Machado F, Myatra SN, Ostermann M, Perner A, Teboul JL, Vincent JL, Walley KR.Challenges in the management of septic shock: a narrative review. Intensive Care Med. 45(4):420-433. 2019. PMID: 30741328.

• Rush B, Fruhstofer C, Walley KR, Celi LA, Brahmania M. Palliative medicine and hospital readmissions in end-stage liver disease. BMJ Support Palliat Care. Feb 13 2019. PMID: 30760459.

• Russell JA, Gordon AC, Walley KR. Early may be better – early low dose norepinephrine in septic shock. Am J Respir Crit Care Med. 199(9):1049-1051, 2019. PMID: 30704272.

• Ukor IF, Walley KR. Vasopressin in vasodilatory shock. Crit Care Clin. 35(2):247-261. 2019. PMID: 30784607

• Ufere NN, Brahmania M, Sey M, Teriaky A, El-Jawahri A, Walley KR, Celi LA, Chung RT, Rush B. Outcomes of in-hospital cardiopulmonary resuscitation for patients with end-stage liver disease. Liver Int. 39(7):1256-1262, 2019. PMID: 30809903.

• Walley KR. Sepsis-induced myocardial dysfunction and mammalian target of rapamycin signalling pathways. Can J Cardiol. 35(7):809-812, 2019. PMID: 31292076.

• Nagendran M, Russell JA, Walley KR, Brett SJ, Perkins GD, Hajjar L, Mason AJ, Ashby D, Gordon AC. Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials. Intens Care Med. 45(6):844-855, 2019. PMID

• Leung AKK, Genga KR, Topchiy E, Cirstea M, Shimada T, Fjell C, Russell JA, Boyd JH, Walley KR. Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients. Sci Rep. 9(1):10588, 2019. PMID: 31332258.

2020

• Shimada T, Topchiy E, Leung AKK, Kong HY, Genga KR, Boryd JH, Russell JA, Oda S, Nakada TA, Hirasawa H, Walley KR. Very Low Density Lipoprotein Receptor sequesters lipopolysaccharide into adipose tissue during sepsis. Crit Care Med, 48:41-48, 2020. PMID: 31651422.

• Linder A, Fjell CD, Inghammar M, Hsu J, Walley KR, Boyd JH, Russell JA. The specific organism: not bacterial gram type: drives the inflammatory response in septic shock. J Innate Immun. 2020;12(2):182-190. PMID: 31242491.

• Rush B, Deol N, Teriyaki A, Sey M, Jairath V, Walley KR, Celi LA, Brahmania M. Lower 90-day hospital readmission rates for esophageal variceal bleeding after TIPS: a nationwide linked analysis.  J Clin Gastroenterology. 54(1):90-95, 2020. PMID: 30829905.

• Walley KR. Discovering causal mechanistic pathways in sepsis-associated ARDS. Am J Respir Crit Care Med, 201(1);2-4, 2020. PMID: 31545649.

• Trinder M, Walley KR, Boyd JH, Brunham LR. Causal inference for genetically determined levels of HDL cholesterol and risk of infectious disease. Arterioscler Thromb Vasc Biol, 40(1):267-278, 2020. PMID: 31694394.

• Thompson M, Mei SHJ, Wolfe D, Champagne J, Fergusson D, Stewart DJ, Sullivan KJ, Doxtator E, Lalu M, English SW, Granton J, Hutton B, Marshall J, Maybee A, Walley KR, Winston B, McIntyre L. Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: an updated systematic review and meta-analysis. EClinicalMedicine, 19:100249, 2020. PMID: 31989101.

• Russell JA, Gordon AC, Williams MD, Boyd JH, Walley KR, Kissoon N. Vasopressor therapy in the ICU. Sem Resp Crit Care Med, 41(5), 2020. PMID: 32820475.

• Rush B, Danziger, J, Walley KR, Kumar A, Zarychanski R, Celi LA. Treatment in disproportionately minority hospitals is associated with increased risk of mortality in sepsis: a national analysis. Crit Care Med, 48(7):962-967, 2020. PMID: 32345833.

• Brahmania M, Wiskar K, Walley KR, Celi LA, Rush B. Lower household income is associated with an increased risk of hospital readmission in patients with decompensated cirrhosis. J Gastroenterol Hepatol, 2020. PMID: 32562577.

• Shimazui T, Nakada TA, Walley KR, Oshima T, Abe T, Ogura H, Shiraishi A, Kushimoto S, Saitoh D, Fujishima S, Mayumi T, Shiino Y, Tarui T, Hifumi T, Otomo Y, Okamoto K, Umemura Y, Kotani J, Sakamoto Y, Sasaki J, Shiraishi SI, Takuma K, Tsuruta R, Hagiwara A, Yamakawa K, Masuno T, Takeyama N, Yamashita N, Ikeda H, Ueyama M, Fujimi S, Gando S; JAAM FORECAST Group. Significance of body temperature in elderly patients with sepsis. Crit Care, 24(1):387, 2020. PMID:

• Reilly JP, Meyer NJ, Shashaty MGS, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD. The ABO Histo-Blood Group, Endothelial Activation, and Acute Respiratory Distress Syndrome Risk in Critical Illness. J Clin Invest, 2020. PMID.

• Rush B, Wiskar K, Fruhstorfer C, Celi LA, Walley KR. The impact of chronic ozone and particulate air pollution on mortality in patients with sepsis across the United States. J Intensive Care Med. 35(10):1002-1007, 2020. PMID 30295138.

• Walley KR, Boyd JH. Lipoprotein biology in sepsis. Crit Care Med. 48(10):1547-1549, 2020.  PMID 32925267.

• Trinder M, Wang Y, Madsen CM, Ponomarev T, Bohunek L, Daisely BA, Kong JHJ, Blauw LL, Nordestgaard BG, Tybjaerg-Hansen A, Wurfel MM, Russell JA, Walley KR, Rensen PCN, Boyd JH, Brunham LR. Inhibition of cholesteryl ester transfer protein preserves high-density lipoprotein cholesterol and improves survival in sepsis. Circulation. 2020 (In press).

(b) Conference Proceedings

 

(c) Other

 

Abstracts

1 Walley KR, Prewitt RM, Wood LDH. Reduced end systolic volume (ESV) during reduced resistive afterload is not due to increased contractility. Fed Proc 39(3):708, 1980.

2 Walley KR, Raff GL, Grover M, Glantz SA. Left ventricular dynamic geometry in the intact and open chest dog. Results of a new method. Fed Proc 40(3):486, 1982.

3 Walley KR, Hersh N, Borow K, Newmann P, Schumacker P, Wood LDH. Reduced resistive afterload does not change the left ventricular end‑systolic pressure‑dimension relation in fentanyl anesthetized dogs. Fed Proc 44(4):A3547, 1985.

4 Walley KR, Becker CJ, Teplinsky K, Hogan R, Wood LDH. Limits of left ventricular function and metabolism during progressive hypoxemia in dogs. Am Rev Respir Dis 133(4):A302, 1986.

5 Walley KR, Becker CJ, Hogan RA, Wood LDH. Determinants of left ventricular contractility during hypoxemia. Fed Proc 45(4):1129, 1986.

6 Teplinsky K, Olman M, Walley KR, Wood LDH. Effect of lactic acidosis on canine hemodynamics and cardiac function. Am Rev Respir Dis 135(4):A115, 1987.

7 Yanos J, Wood LDH, Walley KR, Leisk L, Hall J, Keamy III M. Effect of hypoxic hypoxia on canine diaphragmatic energetics and fatigue. Am Rev Respir Dis 135(3):A54, 1987.

8 Lewis T, Choi E, Melendres J, Garland A, Wood LDH, Walley KR. Response of a canine model of L‑lactic to bicarbonate infusion. Am Rev Respir Dis 137(4):A114, 1988.

9 Walley KR, Ford LE, Wood LDH. Effects of hypoxia and respiratory acidosis on rabbit myocardial muscle force‑velocity relationships. Fed Proc 3(4):A4412, 1989.

10 Cooper DJ, Walley KR. Left ventricular diastolic stiffness and systolic elastance increase during hypovolemic shock. Fed Proc 3(4):A5491, 1989.

11 Walley KR, Cooper DJ, Russell JA. Sodium bicarbonate does not improve hemodynamics and ventricular mechanics during hemorrhagic shock induced lactic acidosis. Am Rev Respir Dis 139(4):A18, 1989.

12 Walley KR, Lewis TH, Wood LDH. Effects of respiratory acidosis on left ventricular mechanics and hemodynamics in dogs. Am Rev Respir Dis 139(4):A18, 1989.

13 Cooper DJ, Walley KR, Russell JA. Sodium bicarbonate does not improve hemodynamics in human metabolic acidosis. Am Rev Respir Dis 139(4):A18, 1989.

14 Ronco J, Belzberg A, Walley KR, Dodek P, Russell JA. Does diastolic dysfunction account for lower oxygen delivery in nonsurvivors of septic and non septic ARDS? Am Rev Respir Dis 139(4):A19, 1989.

15 Cooper DJ. Walley KR, Dodek P, Russell JA. Correlation of decreased plasma ionized calcium and increased lactic acidosis may be due to lactate and bicarbonate binding calcium. Am Rev Respir Dis 141(4):A771, 1990.

16 Cooper DJ, Walley KR. Bicarbonate decreases plasma ionized calcium, increases left ventricular contractility but does not change cardiac output during infused lactic acidosis in pigs. Am Rev Respir Dis 141(4):A774, 1990.

17 Ronco JJ, Phang PT, Wiggs B, Walley KR, Russell JA. Does oxygen consumption depend on oxygen delivery in patients who have the adult respiratory distress syndrome (ARDS)? Am Rev Respir Dis n141(4):A584, 1990.

18 Wiggs BR, Ronco J, Phang PT, Walley KR, Russell JA. More problems with artifactual correlation of oxygen consumption to oxygen delivery. Am Rev Respir Dis 141(4):A585, 1990.

19 Cooper DJ, Thompson C, Walley KR, Gillis RP, Walley PE, Rangno R, Schellenberg RR. Histamine infusion decreases left ventricular contractility in humans. Fed Proc 4(3):A340, 1990.

20 Ronco JJ, Fenwick JC, Phang PT, Cooper DJ, Cunningham KF, Russell JA, Tweedale MG, Walley KR. O₂ delivery, O₂consumption, and the critical O₂ delivery threshold for anaerobic metabolism In septic And nonseptic dying patients. Am Rev Respir Dis 143 (4):A82, 1991.

21 Collins RM, Walley KR, Warriner B. Carbon monoxide impairs myocardial oxygen extraction. Am Rev Respir Dis 143(4):A245, 1991.

22 Cooper DJ, Schellenberg RR, Walley KR. Effect of histamine Infusion on left ventricular contractility in pigs. Am Rev Respir Dis 143 (4):A245, 1991.

23 Wakai Y, Wilcox P, Cooper J, Walley KR, Road J. The effect of tumor necrosis factorµ(TNFµ) on diaphragmatic contractility in anesthetized dogs. Am Rev Respir Dis 143 (4):A560, 1991.

24 Hebert PC, Thompson CR, Walley KR, Gillis RP, Schellenberg RR. Histamine H2 receptor stimulation decreases left ventricular contractility in humans. Am Rev Respir Dis 145 (4):A72, 1992.

25 Herbertson MJ, Werner HA, Iversen K, Walley KR. Decreased myocardial oxygen extraction and contractility in endotoxemia. Am Rev Respir Dis 145 (4):A74, 1992.

26 Hebert PC, Cooper DJ, Wakai Y, Wilcox PG, Road JD, Walley KR. Early decrease in left ventricular contractility after TNFµinfusion. Am Rev Respir Dis 145 (4):A74, 1992.

27 Humer M, Phang PT, Friesen B, Walley KR. Sepsis predisposes gut to ischemia. Am Rev Respir Dis 145 (4):A315, 1992.

28 Ronco JJ, Fenwick JC, Tweeddale MG, Russell JA, Phang PT, Walley KR. Increases in concentration of lactate and arterial and mixed venous pH and pCO₂ gradients identify the critical O₂ delivery threshold in dying humans. Am Rev Respir Dis 145 (4):A791, 1992.

29 Friesen B, Phang PT, Humer M, Walley KR. Does gut become ischemic before the whole body during hemorrhagic shock? Am Rev Respir Dis 145 (4):A791, 1992.

30 Walley KR, Werner H, Herbertson M. Decreased myocardial oxygen consumption during endotoxemia accounted for by decreased myocardial work. FASEB J 7(3):A321, 1993.

31 Herbertson M, Werner H, Goddard C, Russell J, Walley KR. Anti-tumour necrosis factor reduces the hemodynamic disturbance in endotoxemia. FASEB J 7(3):A322, 1993.

32 Werner H, Herbertson MJ, Walley KR. Amrinone increases contractility but dangerously reduces afterload during endotoxemia. Am Rev Respir Dis 147(4):A98, 1993.

33 Herbertson MJ, Werner HA, Studer W, Russell JR, Walley KR. Ibuprofen does not prevent the decreased myocardial contractility in endotoxemia. Am Rev Respir Dis 147(4):A98, 1993.

34 Herbertson MJ, Werner HA, Goddard CM, Russell JR, Walley KR. Anti-tumour necrosis factor ameliorates the decrease in myocardial contractility in endotoxemia. Am Rev Respir Dis 147(4):A202, 1993.

35 Herbertson MJ, Werner HA, Minshall DK, Iversen K, Walley KR. Myocardial blood flow is maintained but redistributed in endotoxemia. Am Rev Respir Dis 147(4):A611, 1993.

36 Studer W, Phang PT, Iverson K, Rudston-Brown B, Walley KR. Does pentoxifylline increase oxygen extraction ratio in porcine models of hemorrhagic and endotoxin shock? Am Rev Respir Dis 147(4):A615, 1993.

37 Miller CC, Miller JWR, Herbertson MJ, Walley KR. Absorption of nitric oxide and production of nitrogen dioxide in the tracheostomized and ventilated pig. Am Rev Respir Dis 147(4):A893, 1993.

38 Harris SL, Henderson BM, Miller CC, Walley KR. Modeling normal and septic shock in porcine pulmonary vasculature. Am J Resp Crit Care Med 149:A439, 1994.

39 Miller CC, Herbertson MJ, Walley KR. Effects of inhaled nitric oxide on early and later phase endotoxin-induced pulmonary hypertension in pigs. Am J Respir Crit Care Med 149:A442, 1994.

40 Goddard CM, Allard MF, Hogg JC, Walley KR. Leukocytes are retained in the coronary circulation and myocardial oxygen extraction is reduced after endotoxin infusion in pigs. Am J Respir Crit Care Med 149:A656, 1994.

• Axler O, Thompson CR, Walley KR, Tousignant C, Verburgt L, Phang PT, Russell J. Comparison of cardiac output using thermodilution, transesophageal echocardiographic and Fick methods in critically ill patients. Am J Respir Crit Care Med 149:A931, 1994.

42 Axler O, Thompson CR, Russell JA, Tousignant C, Dodek P, Walley KR. Changes in filling pressures and left ventricular end-diastolic area following a 500 ml rapid saline bolus do not help in the assessment of volume status. Am J Respir Crit Care Med 149:A933, 1994.

43 Goddard CM, Allard MF, Hogg JC, Walley KR. Blood borne factors decrease left ventricular contractility and induce morphometric changes in an isolated-supported rabbit heart. Am J Respir Crit Care Med 149:A1061, 1994.

44 Herbertson MJ, Werner HA, Walley KR. Platelet activating factor antagonism improves cardiovascular function during endotoxemia. Am J Respir Crit Care Med 151:A447, 1995.

45 Herbertson MJ, Werner HA. Handel J, Walley KR. L-nitro arginine partially reverses decreased myocardial contractility in endotoxemia. Am J Respir Crit Care Med 151:A15, 1995.

46 Granton JT, Goddard CM, Allard MA, Hogg JC, Walley KR. Removal of circulating leukocytes attenuates myocardial dysfunction in an isolated-supported rabbit heart during endotoxemia. Am J Respir Crit Care Med 151:A316, 1995.

47 Granton JT, Phang PT, Russell JA, Walley KR, Marchie P, Lichtenstein SV. Reducing the influence of shared measurement error in oxygen consumption and delivery relationships. Am J Respir Crit Care Med 151:A323, 1995.

48 Goddard CM, Allard MF, Hogg JC, Walley KR. Comparison of contractility in isolated-supported and crystalloid perfused rabbit hearts. Am J Respir Crit Care Med 151:A706, 1995.

49 Goddard CM, Allard MF, Hogg JC, Herbertson MJ, Walley KR. Myocardial leukocyte transit time is increased after endotoxin infusion in pigs. Am J Respir Crit Care Med 151:A316, 1995.

50 Volpatti C, Walley KR, Dodek PM. Nursing demand is a better predictor than midnight census of nursing supply in an ICU. Am J Respir Crit Care Med 151:A291, 1995.

51 Poon BY, Goddard CM, Leaf CD, Russell JA, Walley KR. Glutathione repletion prevents endotoxin-induced decrease in left ventricular contractility in isolated rabbit hearts. Am J Respir Crit Care Med 153(4):A251, 1996.

52 Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. Am J Respir Crit Care Med 153(4):A467, 1996.

53 Granton J, Chittock D, Baigorri F, Russell JA, Walley KR. Comparison of three methods of measuring gastric PCO₂ in a porcine model of cardiac tamponade. Am J Respir Crit Care Med 153(4):A602, 1996.

54 Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL. Pattern of chemokine expression in murine sepsis. Am J Respir Crit Care Med 153(4):A834, 1996.

55 Goddard CM, Poon BY, Hogg JC, Walley KR. Myocardial leukocyte retention during sepsis is heart and not leukocyte dependent. Am J Respir Crit Care Med 153(4):A839, 1996.

56 Walley KR, Lucaks NW, Phan SH, Kunkel SL. Cytokine and chemokine expression in a murine lung injury model of fibrotic ARDS. Am J Respir Crit Care Med 155(4):A89, 1997.

57 Goddard CM, Poon BY, Hogg JC, Wiggs BR, Walley KR. Coronary differential leukocyte transit time and retention during sepsis. Am J Respir Crit Care Med 155(4):A929, 1997.

58 Walley KR, Friesen BP, Humer MF, Phang PT. Small bowel tonometry is more accurate than gastric tonometry in detecting gut ischemia. Am J Respir Crit Care Med 157(3):A105, 1998.

59 Walley KR, McDonald T, Higashimoto Y, Hayashi S. Modulation of pro-inflammatory cytokine production by nitric oxide in acute lung injury. Am J Respir Crit Care Med 157(3):A681, 1998.

60 Simms MG, Walley KR. A mechanism of myocardial dysfunction in sepsis: macrophage / cardiomyocyte interaction. Am J Respir Crit Care Med 157(3):A101, 1998.

61 Walley KR, Simms MG, Poon BY, Goddard CM. Activated neutrophils adhere to and decrease fractional shortening of activated rat cardiac myocytes. Am J Respir Crit Care Med 157(3):A103, 1998.

62 Uusaro A, Chittock D, Russell J, Walley KR. Increased respiratory drive and increased gastric-arterial CO₂ gradient during stress test predict failure of extubation. Am J Respir Crit Care Med 157(3):A850, 1998.

63 Uusaro A, Takala J, Russell J, Walley KR. Gastric mucosal-arterial CO₂ gradient does not reflect systemic or splanching oxygenation after cardiac surgery. Am J Respir Crit Care Med 157(3):A297, 1998.

64 Dhingra VK, Uusaro A, Walley KR. Attenuation of pro-inflammatory cytokine production by adrenergic agents in acute injury. Am J Respir Crit Care Med 159(3):A379, 1999.

65 McDonald KO, Walley KR. Rapid determination of optimal peep for pressure-limited ventilation based on tidal volume. Am J Respir Crit Care Med 159(3):A75, 1999.

66 Patel B, Chittock D, Walley KR. Vasopressin infusion in SIRS and septic shock: a randomized controlled trial. Am J Respir Crit Care Med 159(3):A608, 1999.

67 Dhingra VK, Abel J, Lichtenstein S, Bowering J, Walley KR. A randomized controlled trial of inhaled nitric oxide post cardiopulmonary bypass. Am J Respir Crit Care Med 159(3) A375, 1999.

68 Simms MG, Walley PE, Munt B, Buchowshi D, Walley KR. Characterization of the pattern of septic myocardial dysfunction in mice using echocardiography. FASEB J 13(4):A109, 1999.

69 McDonald TE, Grinman MN, Carthy CM, Walley KR. Endotoxin infusion in rats induces apoptotic and survival pathways in the heart. Am J Respir Crit Care Med 161(3):A461, 2000.

70 Bosan S, Chen YM, Ruehlmann D, Walley KR. An optical-sectioning microscopy based methodology for imaging 3-dimensional structure of capillary beds. Am J Respir Crit Care Med 161(3):A551, 2000.

71 Nakano Y, Coxson HO, Bosan S, Rogers RM, Sciurba FC, Keenan RJ, Walley KR, Hogg JC. Regional distribution of emphysema and the outcome of lung volume reduction surgery (LVRS). Am J Respir Crit Care Med 161(3):A578, 2000.

72 Alscher KT, Phang PT, Walley KR. Enteral feeding decreases the pulmonary cytokine response to endotoxin In mice. Am J Respir Crit Care Med 161(3):A879, 2000.

73 Holmes CL, Walley KR, Grieve E, Lehman T, Race MJ, Russell JA. Vasopressin infusion increases MAP and urine output in patients having severe septic shock. Am J Respir Crit Care Med 161(3):A879, 2000.

74 Zavorsky GS, Walley KR, Sexsmith P, Hunte GS, McKenzie DC, Russell JA. Distribution of pulmonary transit times during severe exercise is altered by volume expansion. Am J Respir Crit Care Med 163(5):A240, 2001.

75 Davani EY, McDonald TE, Walley KR. Neutrophils decrease cardiomyocyte contractility via ICAM-1 and the cytoskeleton. Am J Respir Crit Care Med 163(5):A457, 2001.

76 Dhingra VK, Holmes CL, Russell JA, Bowering J, Abel J, Lichtenstein S, Walley KR. IL-6 associated with myocardial depression post cardiopulmonary bypass surgery. Am J Respir Crit Care Med 163(5):A457, 2001.

77 Russell JA, Honeyman C, Lehman T, Dunlop V, Walley KR. SIRS and organ dysfunction are common after cardiopulmonary bypass. Am J Respir Crit Care Med 163(5):A458, 2001.

78 Holmes CL, Russell JA, McDonald TE, Dai S, Wang YJ, Walley KR. Vasopressin modulates the pro-inflammatory response to endotoxin in a murine model of sepsis. Am J Respir Crit Care Med 163(5):A459, 2001.

79 Walley KR, McDonald T, Wang Y, Dai S, Russell JA. Impact of crystalloid versus colloid resuscitation on the myocardial inflammatory response in rat endotoxemia. Am J Respir Crit Care Med 163(5):A556, 2001.

• Dhingra VK, Fenwick JC, Walley KR, Chittock DR, Ronco JJ. Lack of agreement between thermodilution and Fick cardiac output in critically ill patients. Am J Respir Crit Care Med 163(5):A754, 2001.

• Russell JA, Holmes CL, Sandford AJ, Pare PD, Walley KR. The risk of occurrence of septic shock is increased by TNFa –308A allele and by TNFb –252AA/IL-1RA A₂ interaction in the critically ill. Am J Respir Crit Care Med 165(8):A23, 2002.

• Davani EY, Dai S, McDonald T, Dorscheid D, Walley KR. ICAM-1 activation can modulate cardiomyocyte contractility through cortical cytoskeleton. Am J Respir Crit Care Med 165(8):A174, 2002.

• Boker A, Graham MR, Walley KR, McManus BM, Girling LG, Walker E, Lefevre GR, Mutch WAC. Improved arterial oxygen with biologically variable or fractal ventilation using low tidal volumes in a porcine model of ARDS. Am J Respir Crit Care Med 165(8):A371, 2002.

• Holmes CL, Walley KR, Russell JA. Brussels organ failure-free days in septic ICU patients. Am J Respir Crit Care Med 165(8):A472, 2002.

• Walley KR, Holmes CL, Sandford AJ, Pare PD, Russell JA. IL-6 –174 C/G polymorphism is not associated with outcome differences in critically ill patients. Am J Respir Crit Care Med 165(8):A472, 2002.

• Holmes CL, Russell JA, Sandford AJ, Pare PD, Walley KR. Interaction between polymorphisms of the IL1 receptor antagonist gene intron 2 and the TNFb promoter region in ICU patients. Am J Respir Crit Care Med 165(8):A472, 2002.

• Holmes CL, Russell JA Sandford AJ, Pare PD, Walley KR. TNFb –252 A allele is not associated with septic shock or mortality in ICU patients. Am J Respir Crit Care Med 165(8):A518, 2002.

• Walley KR, McIntyre L, Pare PD, Sandford AJ, Abel J, Lichtenstein S, Russell JA. IL-1-41 and IL-1b polymorphisms associated with blood pressure and cytokine response in post-cardiopulmonary bypass patients. Am J Respir Crit Care Med 165(8):A519, 2002.

• Russell JA, McIntyre L, Abel J, Lichtenstein S, Sandford AJ, Pare PD, Walley KR. C allele of the IL-6 –174 G/C polymorphism is associated with a reduced inflammatory response post cardiopulmonary bypass. Am J Respir Crit Care Med 165(8):A519, 2002.

• Walley KR, Holmes CL, Sandford AJ, Pare PD, Russell JA. Differential association of the TNF-a –308 G/A polymorphism in critically ill patients with and without septic shock. Am J Respir Crit Care Med 165(8):A519, 2002.

• Russell JA, Holmes CL, Sandford AJ, Pare PD, Walley KR. Critically ill patients who have the IL-1ra A₁A₁ genotype have less SIRS and sepsis than patients with other IL-1ra alleles. Am J Respir Crit Care Med 165(8):A519, 2002.

• Sutherland A, Manocha S, Walley KR, Russell JA. C-159T CD14 polymorphism is associated with increased infection in critically ill adults. Am J Resp Crit Care Med 167(7), A162, 2003.

• Kareco T, Russell JA, Walley KR. Use of haplotype-based analysis in association studies. Am J Resp Crit Care Med 167(7), A427, 2003.

• Tee MC, Russell JA, Alikhani A, Dai S, Walley KR. Genotypes associated with lower IL-6 and higher IL-6 production are associated with cardiovascular disease phenotype in cardiac surgical patients. Am J Resp Crit Care Med 167(7), A427, 2003.

• Tee MC, Alikhani A, Engfield M, McDonald TM, Russell JA, Walley KR. Interleukin 10 (IL-10) polymorphisms are associated with differences int eh inflammatory response post cardiopulmonary bypass surgery. Am J Resp Crit Care Med 167(7), A428, 2003.

• Sutherland A, Walley KR, Alikhani A, Minaker S, Russell JA. Structural and promoter polymorphisms of mannose-binding lectin (MBL) are associated with increased prevalence of infection in critically ill patients. Am J Resp Crit Care Med 167(7), A429, 2003.

• Manocha S, Walley KR, Sutherland A, Kareco T, Holmes CL, Russell JA. Fibrinogen β +9006 G-to-A defined haplotype is associated with an improved survival and a reduced occurrence of organ dysfunction in critically ill caucasians. Am J Resp Crit Care Med 167(7), A429, 2003.

• Sutherland A, Russell, JA, Manocha S, Walley KR. Interleukin-6 (IL-6) haplotypes are associated with decreased septic shock and organ dysfunction in critically ill adults. Am J Resp Crit Care Med 167(7), A429, 2003.

• Davani EY, Wang Y, Craig K, Dorscheid DR, Walley KR. During murine endotoxemia PMN cause decreased left ventricular contractility via ICAM-1 binding. Am J Resp Crit Care Med 167(7), A548, 2003.

• Russell JA, Cooper DJ, Walley KR, Holmes CL, Singer J, Hebert P, Granton J, Mehta S, Terins T, VASST Investigators. Vasopressin and septic shock trial (VASST): baseline characteristics and organ dysfunction in vasopressor depenedent patients with septic shock. Am J Resp Crit Care Med 167(7), A548, 2003.

• Holmes CL, Terins T, Cooper DJ, Singer J, Hebert P, Granton J, Mehta S, Walley KR, Russell JA, for the VASST Investigators. Vasopressin in septic shock trial (VASST): screening logs identify modifiable patient exclusions in a randomized controlled trial (RCT). Am J Resp Crit Care Med 167(7), A549, 2003.

• Russell JA, Shapova Y, Manocha S, Sutherland A, Walley KR. T540A TLR2 polymorphism is associated with increased infection and septic shock in critically adults. Am J Resp Crit Care Med 167(7), A838, 2003.

• Francoeur JR, Walley KR, Phang PT. The effect of intraperitoneal arginine on end organ inflammation in endotoxin-induced sepsis in mice. Can J Surg 46:17, 2003.

• Manocha S, Walley KR, Wattanathum A, Groshaus H, Shaw D, Russell JA. Fibrinogen beta -455 G-to-A polymorphism is associated with an improved survival and less organ dysfunction in critically ill patient with sepsis. National Institutes of Health (NIH) Second Annual Symposium on the Functional Genomics of Critical Illness and Injury, November 2003.

• Manocha S, Walley KR, Holmes CL, Russell JA. TNF b +252 A: TNF a -308 G haplotype has a different effect on outcome in patients with SIRS, sepsis, and septic shock. Society of Critical Care Medicine, 33^rd Critical Care Congress 2004.

• Manocha S, Salehifar E, Groshaus H, Walley KR, Russell JA. Use of inhaled Beta-2 agonist is associated with more days alive and free of acute lung injury (ALI). Am J Resp Crit Care Med 169(7), A781, 2004.

• Wattanathum A, Manocha S, Russell JA, Walley KR. IL-10 haplotypes are not associated with survival and organ dysfunction in critically ill patients with the systemic inflammatory response syndrome. Am J Resp Crit Care Med 169(7), A635, 2004.

• Sutherland A, Manocha S, Walley KR, Russell JA. TNFa -308A Allele is associated with increased TNFa levels in cardiopulmonary bypass (CPB) surgery patients. Am J Resp Crit Care Med 169(7), A119, 2004.

• Manocha S, Shaw D, Russell JA, Walley KR. Fibrinogen beta -455 G/A polymorphism is not associated with severity of inflammation or bleeding risk after cardiopulmonary bypass surgery. Am J Resp Crit Care Med 169(7), A119, 2004.

• Shaw D, Minaker S, Engfield M, Russell JR, Walley KR. Interleukin-10 clade 4 (-627C, 734T and 3368G) haplotypes are associated with fewer ICU admissions and a less intense inflammatory response following cardiopulmonary bypass surgery. Am J Resp Crit Care Med 169(7), A119, 2004.

• Davani EY, Wang Y, Walley KR, Dorscheid DR. The rapid effect of erythropoietin on left ventricular function during septic shock. Am J Resp Crit Care Med 169(7), A637, 2004.

• Walley KR, Shaw DM, Sutherland AM, Russell JA. Novel haplotype and polymorphism (673c) of protein C associated with decreased survival and greater organ dysfunction in SIRS. Crit Care Med 32(12 Suppl):A18, 2004

• Russell JA, Shaw DM, Sutherland AM, Walley KR. An interaction of novel haplotypes of protein C and endothelial protein C receptor is associated with decreased survival and increased organ dysfunction in SIRS and sepsis. Crit Care Med. 32(12 Suppl):A18, 2004.

• Walley KR, Shaw DM, Sutherland AM, Russell JA. Protein C -1641 A allele is associated with decreased survival and increased organ dysfunction in sepsis. Crit Care Med. 2004 Dec;32(12 Suppl) A139. Winner of a Research Citation at the SCCM Critical Care Congress.

• Walley KR, Shaw DM, Sutherland AM, Russell JA. Novel polymorphism (2532 T) and haplotype of endothelial protein C receptor is associated with acute lung injury in SIRS. Crit Care Med. 2004 Dec;32(12 Suppl):A141.

• Bateman RM, Hodgson KC, Podor T, Walley KR. Intravital and Exvivo Microvascular Imaging using Dual Fluorescence Multiphoton Microscopy. (Accepted – Focus on Microscopy, Jena, Germany, Mar 18-23, 2005).

• Bateman RM, Hodgson KC, Podor T, Walley KR. In Vivo Microvascular Imaging using MultiPhoton Microscopy and Quantum Dots (Accepted – Experimental Biology, San Diego, California, Apr 1-6, 2005)

• Bateman RM, Hodgson KC, Leong H, Podor T, Walley KR. Intravital and Exvivo Microvascular Imaging using Dual Fluorescence Multiphoton Microscopy (Submitted – 2nd Annual National Research Forum for Young Investigators in Circulatory and Respiratory Health, Winnipeg, Canada, April 28-May 1, 2005)

• Chau E, Devani E, Wang Y, Dai S, Walley KR. Fibrinogen decreases contractility through binding cardiomyocyte ICAM-1. Proceedings of the American Thoracic Society 2:A42, 2005.

• Wong C, Dai S, Sutherland A, Walley KR. Molecular haplotyping of single copy DNA by TaqMan probe-based assay. Proceedings of the American Thoracic Society 2:A151, 2005.

• Dai SW, Wattanathum A, Russell JA, Walley KR. Heme oxygenase-1 haplotypes are associated with survival in patients with pneumonia. Proceedings of the American Thoracic Society 2:A153, 2005.

• Sutherland AM, Walley KR, Russell JA. Haplotype clades in interleukin-6 (IL-6) are associated with low systemic vascular resistance index (SVRI) in cardiac surgery patients. Proceedings of the American Thoracic Society 2:A155, 2005.

• Wattanathum A, Manocha S, Groshaus H, Russell JA, Walley KR. Acute lung injury in critically ill patients with the systemic inflammatory response syndrome is associated with IL-12B haplotype. Proceedings of the American Thoracic Society 2:A319, 2005.

• Bateman RM, Leong H, Podor T, Hodgson KC, Kareco T, Walley KR. Effect of Thrombin on Fibrin Clot Formation using Multiphoton Microscopy and Fractal Dimension Analysis (Submitted – Microscopy and Microanalysis, Honolulu, Hawaii, July 31-Aug 4, 2005).

• Hodgson K, Bateman RM, Walley KR, van Breemen C. Mirovascular geometry of the intact eye revealed with dual channel multiphoton microscopy. Photonics West Conference, San Jose, CA, January 21, 2006.

• Sutherland AM, Wurfel MM, Walley KR, Martin TR, Russell JA. Interleukin-1 receptor associated kinase 4 (IRAK4) G29429A is associated with prevalence of positive bacterial cultures in critically ill patients. Proceedings of the American Thoracic Society 3:A274, 2006.

• Haljan GJ, Sutherland AM, Lau K, Murkin JM, Walley KR. Neurologic outcome after coronary artery bypass surgery is associated with post-operative serum levels of interleukin 1-receptor antagonist. Proceedings of the American Thoracic Society 3:A613, 2006.

• Shaw DM, Page AN, Russell JA, Walley KR. A novel polymorphism of the interleukin-18 receptor-1 (IL-18 R1) gene is associated with increased prevalence of vasodilatory syndrome following cardiopulmonary bypass surgery. Proceedings of the American Thoracic Society 3:A646, 2006.

• Page AN, Shaw DM, Tildesley HD, Russell JA, Walley KR. Association of plasminogen activator inhibitor-1 -837 4G/5G insertion deletion polymorphism and vasodilation in 742 coronary artery bypass graft patients. Proceedings of the American Thoracic Society 3:A647, 2006.

• Tokunaga C, Bateman RM, Boyd J, Wang Y, Walley KR. Early albumin fluid resuscitation compensates cardiac dysfunction in endotoxemia. Proceedings of the American Thoracic Society 3:A649, 2006.

• Haljan GJ, Sutherland AM, Murkin JM, Walley KR. Serum erythropoietin levels increase after coronary artery bypass surgery and are associated with neurological outcome at discharge from hospital. 62^nd Annual Meeting of the Canadian Anesthesiologists’ Society, June 2006.

• Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR. Toll like receptor stimulation in cardiomyocytes decreases contractility via an NF-kB dependent mechanism. Am J Respir Crit Care Med 175:A180, 2007.

• Tokunaga C, Haljan G, Boyd JH, Wang Y, Walley KR. Fibrinogen, fibrinogen degradation products and fibrinogen ¡ (117-133) decrease cardiomyocyte contractility through interaction with ICAM-1. Am J Respir Crit Care Med 175:A441, 2007.

• Russell JA, Walley KR, Singer J, Gordon AC, Hebert P, Cooper J, Mehta S, Granton J, Holmes Boulton CL, Storms, MM, Cook D, Presneill JJ, the VASST Investigators. A Randomised Controlled Trial of Low Dose Vasopressin Versus Norepinephrine Infusion in Patients Who Have Septic Shock. Am J Respir Crit Care Med 175:A508, 2007.

• Holmes Boulton CL, Walley KR, Ayers DM, Gordon AC, Singer J, Russell JA, the VASST Investigators. Septic Shock Mortality Decreased over Time during the Vasopressin and Septic Shock Trial (VASST). Am J Respir Crit Care Med 175:A562, 2007.

• Walley KR. Hemodynamic effects of vasopressin versus norepinephrine in septic shock in the VASST cohort. Am J Respir Crit Care Med 175:A594, 2007.

• Gordon AC, Russell JA, Holmes Boulton CL, Singer J, Storms MM, Walley KR. The Effect of Vasopressin on Acute Renal Failure in Septic Shock. Am J Respir Crit Care Med 175:A596, 2007.

• Haljan GJ, Chan J, Sutherland AM, Murkin JM, Russell JA, Walley KR. Serum VEGF Levels Increase after Coronary Artery Bypass Surgery and Are Associated with Neurological Outcome at Discharge. Am J Respir Crit Care Med 175:A862, 2007.

• Wurfel MM, Gordon AC, Holden TD, Radella F, Stratton S, Rona G, Strout J, Black RA, Nickerson DA, Walley, KR, Russell JA, Martin TR. Variation in the TLR1 Gene Affects TLR1 Surface Expression and Is Associated with Increased Mortality in Septic Shock. Am J Respir Crit Care Med 175:A898, 2007.

• Sham AH, Sutherland AM, Walley KR, Russell JA. From Clinical Association to Functional Analysis: Determining the Effect of IRAK-4 Haplotypes on Innate Immune Response. Am J Respir Crit Care Med 175:A900, 2007.

• Indrambarya T, Boyd JH, Wang Y, Walley KR. The Effect of Arginine Vasopressin on Myocardial Function after Ischemia Reperfusion Injury in a Mouse Model. Am J Respir Crit Care Med 179:A5498, 2009.

• Lee SJ, Boyd JH, Wang Y, Walley KR. Hsp70 Mediates Inflammatory Cardiac Dysfunction Via Toll-Like Receptors: Link between Innate Immune Modulators and Cardiomyocyte Contractility. Am J Respir Crit Care Med 179:A5741, 2009.

• Mehta S, Granton J, Cook D, Ayers D, Singer J, Siau C, Walley KR, Storms M, Cooper J, Holmes C, Hebert P, Gordon A, Presneill J, Russell J. Troponin and CKMB Trends in Patients with Septic Shock Randomized to Vasopressin (VP) or Norepinephrine (NE). Am J Respir Crit Care Med 179:A1564, 2009.

• Mathur S, Boyd JH, Wang Y, Walley KR. CpG C Attenuates the NF-kB Response to TLR4 Ligands. Am J Respir Crit Care Med 179:A5739, 2009.

• Nakada TA, Russell JA, Boyd JH, McLaughlin L, Nakada E, Thair SA, McConechy M, Thain KR, Aguirre-Hernandez R, Walley KR. The GG genotype of Angiotensin II Type 1 Receptor-Associated Protein Gene rs11121816 Polymorphism is Associated with Increased Mortality in Septic Shock. Am J Respir Crit Care Med 181:A1021, 2010.

• Mathur S, Wang Y, Walley KR, Boyd JH. CpG C Preserves Ejection Fraction in an Ischemic Model. Am J Respir Crit Care Med 181:A1101, 2010.

• Boyd JH, Forbes J, Walley KR, Russell JA. Over-resuscitation with fluid in septic shock decreases survival and increases time on the ventilator. Am J Respir Crit Care Med 181:A1137, 2010.

• Thain KR, Nakada T, Boyd J, Walley KR. Discovery of functional single nucleotide polymorphisms and mechanisms of action in the protein C gene. Am J Respir Crit Care Med 183:A5507, 2011.

• Wacharasint P, Nakada T-A, Boyd JH, Russell JA, Walley KR. Minimal Increase Of Arterial Lactate In Septic Shock Is Associated With Increased Mortality. Am J Respir Crit Care Med. 185 A1122, 2012.

• Lalu MM, McIntyre L, Lamontagne F, Bains J, Mei SHJ, Fergusson D, Winston BW, Marshall JC, Walley KR, Courtman D, Stewart DJ. Systematic Review and Meta-Analysis of Mesenchymal Stromal Cells in Pre-Clinical Models of Septic Shock. Am J Respir Crit Care Med. 185 A2215, 2012.

• Nakada T-A, Russell JA, Boyd JH, Thair SA, Nakada E, Oda S, Walley KR. Vacuolar Protein Sorting 13 Homolog D (VPS13D) rs6685273 CC Genotype Is Associated With Increased Interleukin-6 (IL-6) Levels In Vitro And Increased Mortality Of Septic Shock Patients. Am J Respir Crit Care Med. 185 A6004, 2012.

• Russell JA, Walley KR, Boyd J. Polymorphism of V1b receptor is associated with increased risk of serious adverse events during norepinephrine infusion in septic shock. Crit Care Med 40(12):1-328, 2012.

• Nakada T, Boyd J, Walley KR, Russell JA. Polymorphism of angiopoietin-1 Rs4324901 is associated with increased fluid overload and mortality of septic shock. Crit Care Med 40(12):1-328, 2012.

• Wacharasint P, Nakada T-A, Boyd JH, Russell JA, Walley KR. Minimal Increase Of Arterial Lactate In Septic Shock Is Associated With Increased Mortality. Am J Respir Crit Care Med. 185 A1122, 2012.

• Thain KR, Nakada T-A, Boyd JH, Walley KR. A Low Density Lipoprotein (LDL) Receptor Modulator, PCSK9, Is Associated With Increased Mortality In Septic Shock. Am J Respir Crit Care Med. 185 A5999, 2012.

• Nakada T-A, Russell JA, Boyd JH, Thair SA, Nakada E, Oda S, Walley KR. Vacuolar Protein Sorting 13 Homolog D (VPS13D) rs6685273 CC Genotype Is Associated With Increased Interleukin-6 (IL-6) Levels In Vitro And Increased Mortality Of Septic Shock Patients. Am J Respir Crit Care Med. 185 A6004, 2012.

• Meyer NJ, Russell JA, Christie JD, Walley KR. IL1RNCoding SNP Is Associated With Decreased Interleukin-1 Beta And Decreased Mortality In The VASST Septic Shock Cohort. Am J Respir Crit Care Med. 2013.

• Linder A, Fjell C, Levin A, Walley KR, Boyd JH. Small Acute Increases in Serum Creatinine are Associated with Decreased Long Term Survival in the Critically Ill. Am J Respir Crit Care Med. 2014.

• Douglas JJ, Fisher J, Boyd JH, Russell JA, Walley KR. Elevated Plasma Ang-2 Levels Are Associated With Fluid Overload, Organ Dysfunction And Mortality In Human Septic Shock. Am J Respir Crit Care Med. 2014.

• Douglas JJ, Boyd J, Walley KR, Wellman H, Russell JA. Clinical Efficiency Of Vasopressin Has Increased Over Time: A Vasopressin-Norepinephrine Case Matched Propensity Scored Study. Am J Respir Crit Care Med. 2014.

• Kaufman MA, Yin S, Walley KR, Russell JA, Boyd JH. Adverse Outcomes Associated With Fresh Frozen Plasma Transfusion In Critically Ill Patients. Am J Respir Crit Care Med. 2014.

• Linder A, Parson D, Fischer J, Boyd J, Walley KR, Russell JA. Elevated Plasma Levels Of Heparin-Binding Protein (HBP) Predicts Progression To Acute Respiratory Distress Syndrome (ARDS) In Human Septic Shock. Am J Respir Crit Care Med. 2014.

• Mikacenic C, Calfee CS, Matthay MA, Harju-Baker S, Meyer NJ, Russell JA, Walley KR, Lin X, Christie JD, Christiani DC, Wurfel MM. Common Genetic Polymorphisms In FAS And MYLK Are Highly Associated With Plasma Levels Of Soluble Fas In A Critically Ill Population. Am J Respir Crit Care Med. 2014.

• Wurfel MM, Christie JD, Calfee CS, Matthay MA, Barnett I, Meyer NJ, O’Mahony DS, O’Keefe GE, Hakonarson H, Jarvik GP, Walley KR, Russell JA, Lin X, Christiani DC. Validation Of Genome-Wide Association Study Of Acute Respiratory Distress Syndrome Risk Loci In The iSPAAR Consortium. Am J Respir Crit Care Med. 2014.

• Cirstea MS, Thain KR, Boyd JH, Walley KR. Decreased PCSK9 Function Increases Endotoxin Clearance and Decreases the Associated Inflammatory Response. Centre for Heart Lung Innovation, St. Paul’s Hospital and University of British Columbia, Vancouver, Canada. Canadian Cardiovascular Congress, 2014.

• Sullivan KJ, McIntyre L, Lalu M, Mei S, Moher D, Fergusson D, Marshall J, Winston B, Walley K, Jazi M, Stewart D. A systematic review of the reporting of mesenchymal stromal cell (MSC) manufacturing and characterization in pre-clinical, MSC treated, models of sepsis. ISCT. 2015.

• Barnett I, Calfee CS, Matthay M, Meyer NJ, Mikacenic, C, O’Keefe G, Hakonarson H, Sandford A, Obeidat M, Postma DS, Nickle DC, Bosse Y, Jarvik GP, Walley KR, Russell JA, Lin X, Christiani DC, Wurfel MM. A genome-wide association study identifies genetic variation in MBP that is associated with ventilator-free days in patients with ARDS in the iSPAAR Consortium. Am J Resp Crit Care Med. 193:A2659, 2016.

• Topchiy E, Fjell C, Russell JA, Boyd JA, Walley KR. Reduced PCSK9 function is associated with improved outcomes in gram-positive septic shock patients. Am J Resp Crit Care Med. 193:A2718, 2016.

• Topchiy E, Boyd JH, Russell JA, Walley KR. Lipopolysaccharide is cleared from the circulation by hepatocytes via the low density lipoprotein receptor. Am J Resp Crit Care Med. 193:A2719, 2016.

• Trivedi N, Ahuja R, Walley KR, Babina M, Guhl S, Caughey G. Inheritance of loss-of-function tryptase alleles is linked to reduced survival from severe sepsis. Am J Resp Crit Care Med. 193:A2720, 2016.

• Cirstea M, Walley KR, Russell JA, Boyd J. Early High Density Lipoprotein (HDL) level predicts the development of organ dysfunction and mortality in patients presenting with suspected sepsis. Am J Resp Crit Care Med. 193:A2726, 2016.

• Roveran Genga K, Cirstea M, Lo C, Walley K, Russell JA, Boyd JH. PCSK9 Loss-of-Function Genotype and Outcomes of Sepsis. Am J Resp Crit Care Med. 193:A2726, 2016.

• Pisitsak C, Lee JG, Boyd JH, Coxon HO, Russell JA, Walley KR. Increased Ratio of visceral to subcutaneous adipose tissue in septic patients is associated with adverse outcome. Am J Resp Crit Care Med. 193:A3680, 2016.

• Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Palakshappa JA, Ittner CA, Calfee CS, Matthay M, Wang Z, Mikacenic C, Lin X, Barnett I, Walley KR, Russell JA, Christiani DC, Wurfel MM, Christie JD. ABO genetic variation and acute respiratory distress syndrome risk in sepsis. Am J Resp Crit Care Med. 193:A7490, 2016.

• Deol N, Rush B, Teriyaki A, Sey M, Jaraith V, Walley KR, Celi LA, Brahmania M. Lower 90 day readmission rates for esophageal variceal bleeding in patients receiving TIPS: A nationwide linked analysis. Dig Dise Week, 2018.

• Roveran Genga K, Kong H, Wishart D, Borchers C, Brunham L, Cullis P, Walley KR, Boyd JH, Russell JA. Proteomic, Metabolomic and Lipidomic Deficiencies in Human Sepsis Compared to Health – Preliminary Study.  Am J Resp Crit Care Med. 195:A1813, 2018.

• Kong H, Boyd JH, Russell JA, Walley KR. Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Genotype Is Beneficial to Septic Shock Outcome While HMG-CoA Reductase Loss-of-Function Genotype Is Not.  Am J Resp Crit Care Med. 195:A2791, 2018.

• Roveran Genga K, Lo C, Cirstea M, Kong H, Leung AK, Shimada T, Walley KR, Russell JA, Linder A, Boyd JH. PCSK9 Loss-of-Function (LOF) Genotype Is Associated with Decreased Readmission or Death in Sepsis Associated with Shock and/or Pulmonary Dysfunction. Am J Resp Crit Care Med. 195:A4175, 2018.

• Roveran Genga K, Trinder M, Kong H, Leung AK, Shimada T, Walley KR, Russell JA, Brunham L, Boyd JH. Cholesterylester Transfer Protein (CETP) Gain-of-Function (GOF) Genotype R468Q and Development of Sepsis-Associated Acute Kidney Injury (AKI).  Am J Resp Crit Care Med. 195:A4176, 2018.

• Shimada T, Topchiy E, Leung AK, Kong H, Roveran Genga K, Boyd JH, Russell JA, Walley KR, Oda, Hirasawa H. Very Low Density Lipoprotein Receptor Sequesters LPS into Adipose Tissue During Sepsis.  Am J Resp Crit Care Med. 195:A4178, 2018.

• Leung AK, Russell JA, Boyd JH, Walley KR. Very Low Density (VLDL) and Low Density Lipoproteins (LDL) Mediate the Uptake of Pathogen Lipids and Stimulate the Production of IL-1β in THP-1 Macrophages.  Am J Resp Crit Care Med. 195:A4747, 2018.

• Leung AK, Grzelkovski G, Roveran Genga K, Russell JA, Boyd JH, Walley KR. Modulation of the Vascular Endothelial Inflammatory Response by Proprotein Convertase Subtilisin-Kexin Type 9 (PCSK9). Am J Resp Crit Care Med. 195: A4748, 2018.

• Winston BW, Banoei M, McIntyre L, Stewart DJ, Mei SH, Courtman D, Watpool I, Granton JT, Marshall JC, Dos Santos CC, Walley KR, Schlosser K, Fergusson D. Metabolomics Analysis of MSC Therapy in A Phase I Clinical Trial for Septic Shock. Am J Resp Crit Care Med. 195:A6009, 2018.

• Walley KR, Boyd JH, Kong HJ, Russell JA. Low Low-Density Lipoprotein Levels Are Associated With, But Do Not Causally Contribute to, Increased Mortality in Sepsis. Crit Care Med. 2018.

• Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell J, Christie JD, Meyer N, Christiani DC, Wurfel MM. Genetic Inference Implicates the FAS Pathway in Systemic Organ Failure. Am J Resp Crit Care Med. 201:A2589, 2020.

2. NON-REFEREED PUBLICATIONS

(a) Journals

• Cooper DJ, Walley KR, Russell JA. Lactic acidosis (reply). (Letter). Annals of Internal Medicine. 113(3):255-256, 1990.

• Ronco JJ, Phang PT, Walley KR, Wiggs BR, Fenwick JC, Russell JA. Oxygen consumption is independent of changes in oxygen delivery in severe adult respiratory distress syndrome (letter). Am Rev Respir Dis. 145:978-979, 1992.

• Phang PT, Walley KR. Effects of low-dose dopamine on gut ischemia in a porcine model of hemorrhagic shock (letter). J Appl Physiol. 74:1472-1473, 1993.

• Ronco JJ, Fenwick JC, Tweeddale MG, Wiggs BR, Phang PT, Cooper DJ, Cunningham KF, Russell JA, Walley KR. Critical oxygen delivery in patients with sepsis (letter). JAMA. 271:1158-1159, 1994.

• Cooper DJ, Walley KR. Bicarbonate does not increase left ventricular contractility during L- lactic acidemia in pigs (letter). Am J Respir Crit Care Med. 149:1054-1055, 1994.

• Herbertson MJ, Walley KR. Managing shunting in sepsis. Look beyond cardiac output. J Crit Illness 10.161-162, 1995.

• Rudston-Brown B, Draper PN, Warriner B, Walley KR, Phang PT. End-tidal CO₂ after CO₂ embolism (letter). Can J Anaesthesia. 45:913-914, 1998.

• Holmes CL, Walley KR, Russell JA. Vasopressin and cardiac performance (letter). Chest. 121:1723-1724, 2002.

• Dorscheid DR, Walley KR. Introducing critical care’s ongoing reviews of science. Crit Care, 6:461, 2002.

• Patel BM, Chittock DR, Russell JA, Walley KR. Does vasopressin infusion improve the outcome of severe septic-shock without any adverse effects? (letter). Anesthesiology, 98:793, 2003.

• Iijima T, Oguchi T, Kashimoto S, Patel BM, Chittock DR, Russell JA, Walley KR. Does vasopressin infusion improve the outcome of severe septic-shock without any adverse effects? Anesthesiol. 98(3):793, 2003.

• Russell JA, Walley KR. Vasopressin in septic shock (letter). New Engl J Med. 358:2727-2738, 2008.

• Russell JA, Gordon AC, Walley KR. Corticosteroids and the original vasopressin and septic shock trial subgroups (letter). Crit Care Med. 38(1) 338-339, 2010.

• Boyd JH, Walley KR, Russell J. Fluid balance and central venous pressure in sepsis: Small pieces in an enormous puzzle. Crit Care Med. 39(5):1239, 2011.

 

• Walley KR. Septic Cardiomyopathy. In: Acute Cardiac Care: Selected Proceedings from the 10th Summer Conference in Intensive Care Medicine. Mount Prospect, IL: Society of Critical Care Medicine; 2013:15-20.

• Walley KR. Organ Support: Noninvasive Ventilation, Continuous Veno-venous Hemofiltration, and Other Strategies. In: Acute Cardiac Care: Selected Proceedings from the 10th Summer Conference in Intensive Care Medicine. Mount Prospect, IL: Society of Critical Care Medicine; 2013:27-32.

• Walley KR. Initial Pharmacologic Treatment in Acute Coronary Syndrome. In: Acute Cardiac Care: Selected Proceedings from the 10th Summer Conference in Intensive Care Medicine. Mount Prospect, IL: Society of Critical Care Medicine; 2013:41-44.

• Walley KR. Adipose tissue measurements in patients with sepsis (letter). Crit Care Med. 2017.

• Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A. Erratum to: Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp. 5(1):6. 2017 PMID: 28108970.

• Mehta S, Granton J, Gordon AC, Cook DJ, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J, Russell JA; Vasopressin and Septic Shock Trial (VASST) Investigators. Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Crit Care. 4;21(1):98. 2017 PMID: 28468661.

• Pisitsak C, Walley KR. The authors reply. Crit Care Med. 45(3):e332-e333, 2017. PMID:28212234

• Rush, B Walley KR, Celi LA, Rajoriya N, Brahmania M. Necessity of more sensitivity analyses and interpretations from public health perspectives Reply. Hepatology 69(2); 920-921, 2019. PMID: 28922468

(b) Conference Proceedings

 

(c) Other

3. BOOKS

 

(a) Authored

 

(b) Edited

• Walley KR, Associate Editor. Principles of Critical Care, 2nd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 1998.

• Walley KR, Russell JA, Editors. Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach. Cambridge University Press, Cambridge, UK, 1999.

• Walley KR, Section Editor “Cardiovascular System”. Current Opinion in Critical Care. Editor Jean-Louis Vincent. Lippincott Williams & Wilkins, Hagerstown, MD, 2016.

(c) Chapters

 

1 Walley KR, Wood LDH. Shock. In Principles of Critical Care. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY. 1992; Chapter 114. 1393-1416.

2 Walley KR, Wood LDH. Ventricular dysfunction in critical illness. In. Principles of Critical Care. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY. 1992; Chapter 115. 1417-1436.

3 Walley KR. Ventricular dysfunction in sepsis. In. Yearbook of Intensive Care and Emergency Medicine. JL Vincent, Editor. Springer-Verlag Publishers, New York. 1995; pp. 505-517.

4 Walley KR. Mechanism of decreased cardiac function in sepsis. In: Yearbook of Intensive Care and Emergency Medicine. JL Vincent, Editor. Springer-Verlag Publishers, New York, NY, 1997, pp 243-255.

5 Forrest D, Walley KR, Russell JA. Impact of acid-base disorder on individual organ systems. In: Critical Care Nephrology. C Ronco and R Bellomo, Editors. Kluwer Academic Publishers, Dordrecht, The Netherlands, 1997.

6 Manthous C, Walley KR. Introduction: Perspective on critical care. In: Principles of Critical Care, 2nd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 1998.

7 Herbertson MJ, Walley KR. Management of the ICU: A team approach. In: Principles of Critical Care, 2nd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 1998, pp. 11-16.

8 Walley KR, Wood LDH. Shock. In: Principles of Critical Care, 2nd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 1998, pp. 277-302.

9 Walley KR, Wood LDH. Ventricular dysfunction in critical illness. In: Principles of Critical Care, 2nd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 1998, pp. 303-322.

10 Walley KR. Hypoxic hypoxia. In: Update in Intensive Care and Emergency Medicine, JL Vincent Editor. 33. Tissue Oxygenation in Acute Medicine, WJ Sibbald, K.Mesmer, and MP Fink, Editors. Springer, Berlin, 1998, pp 81-97.

11 Dhingra V, Russell JA, Walley KR. Overview, clinical evaluation, and chest radiology of ARDS. In Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach. JA Russell and KR Walley, Editors. Cambridge University Press, Cambridge, UK, 1999, pp 6-27.

12 Walley KR, Russell JA. Pulmonary Pathophysiology in ARDS. In Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach. JA Russell and KR Walley, Editors. Cambridge University Press, Cambridge, UK, 1999, pp 80-106.

13 Walley KR, Russell JA. Cardiovascular Management of ARDS. In Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach. JA Russell and KR Walley, Editors. Cambridge University Press, Cambridge, UK, 1999, pp 107-138.

14 Russell JA, Dhingra V, Walley KR. Clinical Assessment and Total Patient Care. In Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach. JA Russell and KR Walley, Editors. Cambridge University Press, Cambridge, UK, 1999, pp 183-232.

15 Walley KR. Gas exchange in the heart. In: Pulmonary and Peripheral Gas Exchange in Health and Disease. Roca J, Rodriguez-Roisin R, Wagner PD, Editors Marcel Dekker, Inc., New York, NY, 2000, pp 359-381.

16 Bosan S, Walley KR. Models of tissue oxygen uptake and microcirculatory blood flow. In Respiratory-Circulatory Interaction in Health and Disease. Scharf S, Pinsky M, Magder S, Editors. Marcel Dekker, Inc. New York, NY, 2001, pp 113-144.

• Holmes CL, Walley KR. Cardiovascular Management of ARDS. In Acute Respiratory Distress Syndrome. Seminars in Respiratory and Critical Care Medicine. Hall JB, Schmidt G, Editors. Thieme, New York, NY, 2001.

• Holmes CL, Walley KR. Shock. In Intensive Care in Nephrology. P Murray, HR Brady, JB Hall, Editors, Martin Dunitz London, UK, 2005, pp 3-18.

• Walley KR. Shock. In: Principles of Critical Care, 3nd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 2005, pp 249-265.

 

• Walley KR. Ventricular dysfunction in critical illness. In: Principles of Critical Care, 3rd Edition. JB Hall, GA Schmidt, and LDH Wood, Editors. McGraw Hill Publishers, New York, NY, 2005, 267-282.

• Manocha S, Walley KR. Adjunctive Respiratory Therapy. In: Textbook of Critical Care. Fink MP, Abraham E, Vincent J-L, Kochanek PM, Editors, Elsevier Saunders, USA, 2005, pp 539-544.

• Manocha S, Walley KR. Adjunctive Respiratory Therapy. In: Textbook of Critical Care, 6^th Edition. Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink MP, Editors, Elsevier Saunders, USA, 2011, pp 364-368.

• Walley KR. Shock. In: Principles of Critical Care, 4th Edition. JB Hall and GA Schmidt, Editors. McGraw Hill Publishers, New York, NY, 2015, pp 249-262.

 

• Walley KR. Ventricular dysfunction in critical illness. In: Principles of Critical Care, 4th Edition. JB Hall and GA Schmidt, Editors. McGraw Hill Publishers, New York, NY, 2015, 266-278.

• Russell JA, Linder A, Sweet D, Boyd J, Walley KR. Advances in sepsis (Chapter 18). In Lalwani AK and Pfister MHF (eds) Recent Advances in Otolaryngology-Head and Neck Surgery, 4th Edition, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, 2015, 339-382.

• Douglas JJ, Boyd JH, Walley KR. Septic Cardiomyopathy: Quo vadis? From past-to-the future. In: Frontiers in Myocardia; Vol. 1: Septic Cardiomyopathy: from bench-to-bedside. Bentham eBooks, Bentham Science Publishers, 2016.

• Manocha S, Walley KR. Adjunctive Respiratory Therapy In: Textbook of Critical Care, 7^th Edition. Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink MP, Editors, Elsevier Saunders, USA, 2016, 385-388.

• Walley KR. Ventricular function viewed from a time-varying elastance perspective. Cardiopulmonary Monitoring: Basic Physiology, Tools, and Bedside Management. Magder S, Malhotra A, Hardin C, Hibbert K, Editors. Springer, USA, 2019.

2. PATENTS

1 Protein C Polymorphisms, U.S. Patent No. 7,820,376. European Patent No. 1507872.

2 Plasminogen Activator Inhibitor-1 (PAI-1) Haplotypes Predict Outcome in Critically Ill Patients, US # 105/549,804

3 Endothelial Protein C Receptor Polymorphisms Predict Outcome in Patients with Systemic Inflammatory Response, US # 10/591,263

4 Thrombomodulin Polymorphisms Predict Outcome in Patients with Systemic Inflammatory Response Syndrome, US# 10/591,325

5 TLR2 Polymorphisms Predict Incidence and Type of Infection in Patients with Systemic Inflammatory Response Syndrome, US# 10/591,224

6 Coagulation Factor 3 (Tissue Factor) Polymorphisms Predict Outcome in Patients with Systemic Inflammatory Response Syndrome, US# 12/090,613

7 Interferon Gamma Polymorphism Predicts Outcome in Patients with Systemic Inflammatory Response Syndrome, US# 12/304,104

8 Vasopressin Pathway Gene Polymorphisms Predict Outcome in Critically Ill Patients, US#12/162,066

9 Improved Response Polymorphisms for XIGRIS^TM, US# 12/160,889

10 Serpine1 Polymorphisms are Predictive of Risk of Death and Response to Activated Protein C Administration, US# 12/295,232

11 MAP3K14 Polymorphisms as Indicators of Subject Outcome in Critically Ill Subjects

12 Methods and uses for Proprotein Convertase Subtilisin Kexin 9 (PCSK9) inhibitors. US# 61/648,319

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